PMID- 15340219
OWN - NLM
STAT- MEDLINE
DCOM- 20050318
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 27
IP  - 9
DP  - 2004 Sep
TI  - Rubus croceacanthus Leveille inhibits mast cell-mediated anaphylactic-like 
      reaction and tumor necrosis factor-alpha secretion.
PG  - 1359-63
AB  - This work aims at examining the effect of the concentrated methanol extract of 
      Rubus croceacanthus Leveille (RCL) on mast cell-mediated anaphylactic-like 
      reaction in a murine model. RCL inhibited compound 48/80-induced systemic 
      anaphylactic-like reaction. When RCL was given as pre-treatment at concentrations 
      ranging from 0.01 to 1 mg/ml, the histamine release from rat peritoneal mast 
      cells induced by compound 48/80 or anti-dinitrophenyl (DNP) immunoglobulin E 
      (IgE) was reduced in a dose-dependent manner. RCL also inhibited passive 
      cutaneous anaphylaxis activated by anti-DNP IgE. In addition, RCL inhibited 
      phorbol 12-myristate 13-acetate and A23187-induced tumor necrosis factor-alpha 
      secretion from human mast cell line HMC-1 cells. These results indicate that RCL 
      may possess a strong anti-anaphylactic activity.
FAU - Moon, Phil-Dong
AU  - Moon PD
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Jeonbuk, 570-749, South Korea.
FAU - Choi, In-Young
AU  - Choi IY
FAU - Na, Ho-Jeong
AU  - Na HJ
FAU - Jeong, Hyun-Ja
AU  - Jeong HJ
FAU - Kim, Cheorl-Ho
AU  - Kim CH
FAU - Kim, Hyung-Ryong
AU  - Kim HR
FAU - Kim, Yun-Kyung
AU  - Kim YK
FAU - Park, Seong Kyu
AU  - Park SK
FAU - Hong, Seung-Heon
AU  - Hong SH
FAU - Kim, Hyung-Min
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Anaphylaxis/chemically induced/drug therapy/prevention & control
MH  - Animals
MH  - Cell Line
MH  - Histamine/metabolism
MH  - Humans
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Rosaceae/*chemistry
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors
EDAT- 2004/09/02 05:00
MHDA- 2005/03/19 09:00
CRDT- 2004/09/02 05:00
PHST- 2004/09/02 05:00 [pubmed]
PHST- 2005/03/19 09:00 [medline]
PHST- 2004/09/02 05:00 [entrez]
AID - JST.JSTAGE/bpb/27.1359 [pii]
AID - 10.1248/bpb.27.1359 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2004 Sep;27(9):1359-63. doi: 10.1248/bpb.27.1359.