PMID- 15340545
OWN - NLM
STAT- MEDLINE
DCOM- 20050826
LR  - 20061115
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 17
IP  - 4
DP  - 2003 Dec
TI  - [Relationship between human herpesvirus 6 infection and oral squamous cell 
      carcinoma].
PG  - 334-6
AB  - OBJECTIVE: To study the relationship between human herpesvirus 6 (HHV-6) and oral 
      squamous cell carcinoma. METHODS: The serum anti-HHV-6 antibody titers from oral 
      squamous cell carcinoma patients and control subjects were detected by indirect 
      immunofluorescence assay. HHV-6 DNA in peripheral blood mononuclear cells from 
      oral squamous cell carcinoma patients and control subjects was amplified by PCR 
      with primers from sequence of HHV-6 and the specificity was confirmed by 
      Southern-blot hybridization with an internal probe oligonucleotide. An 
      immunohistochemical staining using rabbit anti-HHV-6 antibody was used to detect 
      HHV-6 antigen in oral tumor tissues from oral squamous cell carcinoma patients. 
      RESULTS: Significantly higher proportion of patients with oral carcinoma (16/16) 
      had IgG antibody to HHV-6 in sera compared with those (12/16) in control 
      subjects, and geometric mean titer of these two groups was 1:118 and 1:64 
      respectively (P less than 0.05). The detectable rate of HHV-6 DNA in peripheral 
      blood mononuclear cells for the above groups was 10/16 and 6/16 respectively (P 
      less than 0.05). HHV-6 antigens were positive in 9 out of 12 oral tumor cases and 
      in only 2 out of 8 pericancerous tissues the difference between these two groups 
      was also significant (P less than 0.05). CONCLUSION: These results demonstrated 
      the frequent presence of HHV-6 in oral squamous cell carcinoma, therefore, HHV-6 
      possibly play a role in the pathogenesis of oral squamous cell carcinoma.
FAU - Liu, Jun-lian
AU  - Liu JL
AD  - Department of Dermatology, The No.306 Hospital of PLA, Beijing 100101, China.
FAU - Xu, Zhi-kai
AU  - Xu ZK
FAU - Zhao, Yu
AU  - Zhao Y
FAU - Jin, Yan
AU  - Jin Y
FAU - Dai, Yi-min
AU  - Dai YM
FAU - Yao, Kun
AU  - Yao K
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Carcinoma, Squamous Cell/*virology
MH  - DNA, Viral/blood
MH  - Herpesviridae Infections/*complications/virology
MH  - Herpesvirus 6, Human/genetics/immunology/*isolation & purification
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Infant
MH  - Mouth Neoplasms/*virology
EDAT- 2004/09/02 05:00
MHDA- 2005/08/27 09:00
CRDT- 2004/09/02 05:00
PHST- 2004/09/02 05:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2004/09/02 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Dec;17(4):334-6.