PMID- 15341435
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20190917
IS  - 0936-6555 (Print)
IS  - 0936-6555 (Linking)
VI  - 16
IP  - 5
DP  - 2004 Aug
TI  - First spinal axis segment irradiation with spot-scanning proton beam delivered in 
      the treatment of a lumbar primitive neuroectodermal tumour. Case report and 
      review of the literature.
PG  - 326-31
AB  - Primary intraspinal primitive neuroectodermal tumour (PNET) is a rare tumour 
      entity. The optimal therapeutic management is unclear but, in general, this 
      tumour is treated with surgery followed by radiotherapy and chemotherapy. Proton 
      beam radiation therapy (PT) offers superior dose distributional qualities 
      compared with X- or gamma rays, as the dose deposition occurs in a modulated 
      narrow zone called the Bragg peak. As a result, organs at risk are optimally 
      speared. Here, we present a patient treated with the first spinal axis segment 
      irradiation using spot-scanning PT with a single field, combined with 
      conventional cranio-spinal axis radiotherapy after surgery and chemotherapy, and 
      an extensive review of the literature outlining the clinical features and 
      treatment modality of spinal PNET.
FAU - Weber, D C
AU  - Weber DC
AD  - Division of Radiation Medicine, Proton Therapy Program, Paul Scherrer Institute, 
      Villigen, Switzerland. damien.weber@psi.ch
FAU - Rutz, H P
AU  - Rutz HP
FAU - Lomax, A J
AU  - Lomax AJ
FAU - Schneider, U
AU  - Schneider U
FAU - Lombriser, N
AU  - Lombriser N
FAU - Zenhausern, R
AU  - Zenhausern R
FAU - Goitein, G
AU  - Goitein G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Oncol (R Coll Radiol)
JT  - Clinical oncology (Royal College of Radiologists (Great Britain))
JID - 9002902
RN  - 0 (Protons)
SB  - IM
CIN - Clin Oncol (R Coll Radiol). 2004 Aug;16(5):324-5. PMID: 15341434
MH  - Adult
MH  - Axis, Cervical Vertebra/radiation effects
MH  - Brain Neoplasms/*radiotherapy
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - Intestine, Small/pathology/radiation effects
MH  - Kidney/pathology/radiation effects
MH  - Lumbar Vertebrae/diagnostic imaging/pathology/radiation effects
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuroectodermal Tumors, Primitive/*radiotherapy
MH  - *Proton Therapy
MH  - Radiography
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Conformal/adverse effects/*methods
MH  - Spinal Cord/pathology/radiation effects
RF  - 29
EDAT- 2004/09/03 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/03 05:00
PHST- 2004/09/03 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/03 05:00 [entrez]
AID - S0936-6555(04)00048-2 [pii]
AID - 10.1016/j.clon.2004.03.002 [doi]
PST - ppublish
SO  - Clin Oncol (R Coll Radiol). 2004 Aug;16(5):326-31. doi: 
      10.1016/j.clon.2004.03.002.