PMID- 15342011
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20071115
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 16
IP  - 5
DP  - 2004 Oct
TI  - Inhibitory killer Ig-like receptor genes and human leukocyte antigen class I 
      ligands in haematopoietic stem cell transplantation.
PG  - 634-43
AB  - Identification of inhibitory killer Ig-like receptor (KIR) genes and their 
      cognate human leukocyte antigen (HLA) class I ligands in donor-recipient pairs 
      for patients undergoing haematopoietic stem cell transplantation (HCT) as 
      treatment for haematopoietic malignancies has recently gained considerable 
      interest. One incentive for these studies is to identify potential donors who are 
      not HLA identical with the recipient but who still could serve as acceptable and 
      potentially preferred donors based on their KIR genotype. It is demonstrated that 
      a majority of individuals have at least one inhibitory KIR gene for which they 
      lack the cognate HLA class I ligand. Therefore, the clinical benefits conferred 
      by 'missing KIR ligand' might not be limited only to HLA mismatched 
      donor-recipient combinations but may be applicable also to HLA identical 
      transplants and even autologous HCT.
FAU - Dupont, Bo
AU  - Dupont B
AD  - Immunology Program, Department of Medicine, Memorial Sloan-Kettering Cancer 
      Center, 1275 York Avenue, New York, New York 10021, USA. b_dupont@ski.mskcc.org
FAU - Hsu, Katharine C
AU  - Hsu KC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Animals
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Phylogeny
MH  - Receptors, Immunologic/*genetics
MH  - Receptors, KIR
RF  - 57
EDAT- 2004/09/03 05:00
MHDA- 2005/02/23 09:00
CRDT- 2004/09/03 05:00
PHST- 2004/09/03 05:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/09/03 05:00 [entrez]
AID - S0952-7915(04)00119-0 [pii]
AID - 10.1016/j.coi.2004.07.013 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2004 Oct;16(5):634-43. doi: 10.1016/j.coi.2004.07.013.