PMID- 1534305
OWN - NLM
STAT- MEDLINE
DCOM- 19920702
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 6
IP  - 6
DP  - 1992 Jun
TI  - Identification of a growth suppression domain within the retinoblastoma gene 
      product.
PG  - 953-64
AB  - To date, all naturally occurring retinoblastoma susceptibility gene (RB) 
      mutations known to be compatible with stable protein expression map to the T/E1A 
      and cellular protein-binding region (the "pocket" domain). This domain extends 
      from residue 379 to 792. When full-length RB and certain truncated forms were 
      synthesized in human RB -/- cells, we found that the minimal region necessary for 
      overt growth suppression extended from residue 379 to 928. A functional pocket 
      domain and sequences extending from the carboxy-terminal boundary of the pocket 
      to the carboxyl terminus of the protein were both necessary for growth 
      suppression. Both sets of sequences were also required for E2F binding; hence, 
      the two functions may be linked.
FAU - Qin, X Q
AU  - Qin XQ
AD  - Division of Neoplastic Disease Mechanisms, Dana Farber Cancer Institute, Harvard 
      Medical School, Boston, Massachusetts 02115.
FAU - Chittenden, T
AU  - Chittenden T
FAU - Livingston, D M
AU  - Livingston DM
FAU - Kaelin, W G Jr
AU  - Kaelin WG Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Adenovirus Early Proteins)
RN  - 0 (Antigens, Polyomavirus Transforming)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Oncogene Proteins, Viral)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Adenovirus Early Proteins
MH  - Antigens, Polyomavirus Transforming/*metabolism
MH  - Base Sequence
MH  - Binding Sites
MH  - Blotting, Western
MH  - *Cell Division
MH  - Cell Line
MH  - Fluorescent Antibody Technique
MH  - Growth Inhibitors/*metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Oncogene Proteins, Viral/*metabolism
MH  - Phosphorylation
MH  - Recombinant Fusion Proteins/metabolism
MH  - Retinoblastoma Protein/*metabolism
EDAT- 1992/06/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1992/06/11 19:15
PHST- 1992/06/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1992/06/11 19:15 [entrez]
AID - 10.1101/gad.6.6.953 [doi]
PST - ppublish
SO  - Genes Dev. 1992 Jun;6(6):953-64. doi: 10.1101/gad.6.6.953.