PMID- 15345211
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1092-8472 (Print)
IS  - 1092-8472 (Linking)
VI  - 7
IP  - 5
DP  - 2004 Oct
TI  - Treatment of Helicobacter pylori in Pediatrics.
PG  - 407-412
AB  - Helicobacter pylori (H. pylori) is among the most common bacterial infections in 
      humans. In 1982, H. pylori was discovered by Marshal and Warren, demonstrating an 
      association between H. pylori and ulcer disease. H. pylori is a gram-negative, 
      S-shaped rod that produces enzymes like urease, catalase and oxidase. The 
      mechanism of acquisition and transmission of H. pylori is unclear, although the 
      most likely mode of transmission is fecal-oral and oral-oral. The mode of 
      transmission is supported by studies that demonstrate viable H. pylori organisms 
      can be cultured from the stool or vomitus of infected patients. Risk factors such 
      as minimal education and low socio-economic status during childhood affect the 
      prevalence. Children infected with H. pylori develop histologic chronic active 
      gastritis despite the fact that they are generally asymptomatic. A small 
      percentage of these children will go on to develop peptic ulcer disease, and even 
      gastric cancer. In contrast, the association of abdominal pain and H. pylori 
      infection remains controversial. In the year 2000, the North American Society of 
      Pediatric Gastroenterology guidelines on H. pylori reported that there is no 
      evidence demonstrating a link between H. pylori-associated gastritis and 
      abdominal pain, except in rare cases in which gastric or duodenal ulcer disease 
      is present. Currently, treatment with a combination of two antimicrobial agents 
      in conjunction with a proton pump inhibitor (PPI) continues to be recommended for 
      the treatment of H. pylori associated peptic ulcer disease.
FAU - Blanchard, Samra S
AU  - Blanchard SS
AD  - Department of Pediatrics, Division of Gastroenterology, Rainbow Babies & 
      Children's Hospital and Case Western Reserve University, Cleveland, OH 44106 USA. 
      Sjc2@po.cwru.edu
FAU - Bauman, Lara
AU  - Bauman L
FAU - Czinn, Steven J
AU  - Czinn SJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Treat Options Gastroenterol
JT  - Current treatment options in gastroenterology
JID - 9815941
EDAT- 2004/09/04 05:00
MHDA- 2004/09/04 05:01
CRDT- 2004/09/04 05:00
PHST- 2004/09/04 05:00 [pubmed]
PHST- 2004/09/04 05:01 [medline]
PHST- 2004/09/04 05:00 [entrez]
AID - 10.1007/s11938-004-0053-x [doi]
PST - ppublish
SO  - Curr Treat Options Gastroenterol. 2004 Oct;7(5):407-412. doi: 
      10.1007/s11938-004-0053-x.