PMID- 15348103 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20050228 LR - 20191026 IS - 0957-4530 (Print) IS - 0957-4530 (Linking) VI - 10 IP - 9 DP - 1999 Sep TI - Blood interactions with plasticized poly(vinyl chloride): relevance of plasticizer selection. PG - 527-31 AB - An investigation has been made of blood interactions with plasticized poly(vinyl chloride) (PVC) biomaterials in tubular form, taking into account the influence on the blood response of the polymer, antithrombotic agent, blood condition and test procedure. In vitro and ex vivo procedures were used to achieve a comparison between PVC plasticized with di- (2-ethylhexyl)phthalate (DEHP) and with tri-(2-ethylhexyl)trimellitate (TEHTM). The blood response was monitored in terms of the measurement of fibrinogen adsorption capacity, thrombin-antithrombin III complex (TAT) and the complement component C3a. Surface characterization of the polymers was performed by X-ray photoelectron spectroscopy (XPS). The data obtained indicate that in comparison with DEHP-PVC, there is a higher reactivity for TEHTM-PVC, which correlates with the plasticizer distribution at the polymer surface. CI - Copyright 1999 Kluwer Academic Publishers FAU - Yin, H Q AU - Yin HQ AD - Bioengineering Unit, University of Strathclyde, Glasgow, UK. FAU - Zhao, X B AU - Zhao XB FAU - Courtney, J M AU - Courtney JM FAU - Blass, C R AU - Blass CR FAU - West, R H AU - West RH FAU - Lowe, G D AU - Lowe GD LA - eng PT - Journal Article PL - United States TA - J Mater Sci Mater Med JT - Journal of materials science. Materials in medicine JID - 9013087 EDAT- 2004/09/07 05:00 MHDA- 2004/09/07 05:01 CRDT- 2004/09/07 05:00 PHST- 2004/09/07 05:00 [pubmed] PHST- 2004/09/07 05:01 [medline] PHST- 2004/09/07 05:00 [entrez] AID - 238375 [pii] AID - 10.1023/a:1008912213420 [doi] PST - ppublish SO - J Mater Sci Mater Med. 1999 Sep;10(9):527-31. doi: 10.1023/a:1008912213420.