PMID- 15351502
OWN - NLM
STAT- MEDLINE
DCOM- 20051108
LR  - 20220408
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 152
IP  - 2
DP  - 2004 Sep 17
TI  - Neuropathology of seizures in the immature rabbit.
PG  - 143-52
AB  - Acute morphologic changes of brain due to chemically induced seizures are studied 
      in developing rabbits. Accordingly, rabbits of postnatal days 6 and 7 (p6-7) and 
      p10-12 are injected with a single dose of 1-6 mg/kg kainic acid (KA) 
      intraperitoneally (i.p.) or injected with a single dose of 200-300 mg/kg 
      pilocarpine subcutaneously (s.c.). Many animals developed seizures of varying 
      severity and length. Histologic examination of brain 2 days following injection 
      showed that KA-induced seizures did not cause neuronal death. Pilocarpine-induced 
      seizures resulted in neuronal death mainly involving the CA1 region of 
      hippocampus. In the p6-7 group, only a small number of brains were involved, 
      lesions were mild and limited to CA1. In the p10-12 group, majority of the brains 
      were damaged, lesions were relatively severe, and in some brains extended beyond 
      the CA1 region involving the subiculum, CA3, cortex, and amygdala. Measurements 
      of physiologic parameters indicate that these changes were not secondary to 
      hypoxemia during seizures. However, there was hypotension and hyperthermia, both 
      of which may contribute to brain damage during seizures. The findings suggest 
      that pilocarpine-induced seizures during the second postnatal week in rabbits is 
      a useful model to study the morphologic changes of brain due to seizure in the 
      developing animal and also to assess the systemic physiologic alterations during 
      seizures.
FAU - Towfighi, Javad
AU  - Towfighi J
AD  - Department of Pathology (Anatomic Pathology), The Milton S. Hershey Medical 
      Center, The Pennsylvania State College of Medicine, 500 University Drive, P.O. 
      Box 850, Hershey, PA 17033, USA. jtowfighi@psu.edu
FAU - Housman, Cathy
AU  - Housman C
FAU - Brucklacher, Robert
AU  - Brucklacher R
FAU - Vannucci, Robert C
AU  - Vannucci RC
LA  - eng
GR  - P01HD30704/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Convulsants)
RN  - 0 (Muscarinic Agonists)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain Damage, Chronic/*etiology/*pathology/physiopathology
MH  - Convulsants
MH  - Disease Models, Animal
MH  - Fever/etiology/physiopathology
MH  - Hypotension/etiology/physiopathology
MH  - Kainic Acid
MH  - Muscarinic Agonists
MH  - Nerve Degeneration/etiology/pathology/physiopathology
MH  - Neurons/pathology
MH  - Pilocarpine
MH  - Prosencephalon/growth & development/*pathology/physiopathology
MH  - Rabbits
MH  - Seizures/*complications/*pathology/physiopathology
EDAT- 2004/09/08 05:00
MHDA- 2005/11/09 09:00
CRDT- 2004/09/08 05:00
PHST- 2004/06/17 00:00 [accepted]
PHST- 2004/09/08 05:00 [pubmed]
PHST- 2005/11/09 09:00 [medline]
PHST- 2004/09/08 05:00 [entrez]
AID - S0165-3806(04)00205-6 [pii]
AID - 10.1016/j.devbrainres.2004.06.009 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2004 Sep 17;152(2):143-52. doi: 
      10.1016/j.devbrainres.2004.06.009.