PMID- 15351939
OWN - NLM
STAT- MEDLINE
DCOM- 20050418
LR  - 20080805
IS  - 0494-1373 (Print)
IS  - 0494-1373 (Linking)
VI  - 52
IP  - 3
DP  - 2004
TI  - [Body mass index and serum and sputum TNF-alpha levels relation in asthma and 
      COPD].
PG  - 256-61
AB  - Previous studies have revealed the relationship between asthma with obesity and 
      low body mass index (BMI) with chronic obstructive pulmonary disease (COPD). 
      Tumor necrosis factor-alpha (TNF-alpha) is thought to be related with low BMI. 
      The aim of this study was to determine sputum and serum TNF-alpha levels in 
      patients with COPD and asthma and to evaluate whether these parameters had 
      correlation with BMI. Thirty patients with moderate persistent asthma and 26 
      patients with moderate -severe COPD were included. After BMI values were 
      calculated, sputum was induced by inhalation of hypertonic saline solution and 
      blood was drawn for analysis of serum TNF-alpha levels. There were significant 
      differences in age, serum and sputum TNF-alpha levels between asthma and COPD 
      subjects (Sputum TNF-alpha: asthma; 513 +/- 151 pg/mL-COPD: 333 +/- 126 pg/mL, p< 
      0.001; Serum TNF-alpha: asthma; 332 +/- 114 pg/mL-COPD: 197 +/- 81 pg/mL, p< 
      0.001), however there was no difference in BMI (asthma; 28 +/- 5.7-COPD; 26.6 +/- 
      12.9, p= 0.1). Patients were divided into four categories according to their BMI 
      values as underweight, normal, overweight and obese. In asthmatics; there were 12 
      (40%) obese and 11 (36%) overweight patients while 9 (34%) of COPD patients were 
      underweight. No significant difference was observed among these four groups 
      according to serum-sputum TNF-alpha and smoking history both in asthmatics and in 
      COPD subjects. While there was no correlation between BMI and serum-sputum 
      TNF-alpha levels, BMI was significantly correlated with both smoking history and 
      duration of disease in COPD patients. As a result, most of the asthmatic patients 
      were described as overweight and obese while no such variation was noted in the 
      COPD patients. The induced sputum TNF-alpha levels has no additional benefit on 
      serum TNF-alpha levels which has already known to be associated with BMI.
FAU - Basyigit, Ilknur
AU  - Basyigit I
AD  - Pulmonary Diseases, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. 
      dr_basyigit@yahoo.com
FAU - Yildiz, Fusun
AU  - Yildiz F
FAU - Yildirim, Elif
AU  - Yildirim E
FAU - Boyaci, Hasim
AU  - Boyaci H
FAU - Ilgazli, Ahmet
AU  - Ilgazli A
LA  - tur
PT  - English Abstract
PT  - Journal Article
TT  - Astimli ve KOAH'li hastalarda vucut kitle indeksi ile balgam ve serum TNF-alpha 
      duzeyi arasindaki iliski.
PL  - Turkey
TA  - Tuberk Toraks
JT  - Tuberkuloz ve toraks
JID - 0417364
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Asthma/*epidemiology/etiology/pathology
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*epidemiology/etiology/pathology
MH  - Severity of Illness Index
MH  - Sputum/metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Turkey/epidemiology
EDAT- 2004/09/08 05:00
MHDA- 2005/04/19 09:00
CRDT- 2004/09/08 05:00
PHST- 2004/09/08 05:00 [pubmed]
PHST- 2005/04/19 09:00 [medline]
PHST- 2004/09/08 05:00 [entrez]
PST - ppublish
SO  - Tuberk Toraks. 2004;52(3):256-61.