PMID- 15352553
OWN - NLM
STAT- MEDLINE
DCOM- 20041014
LR  - 20181113
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 68
IP  - 3
DP  - 2004 Jul
TI  - Evaluation of a ceftiofur-washed whole cell Streptococcus suis bacterin in pigs.
PG  - 236-40
AB  - The efficacy of currently available washed whole cell Streptococcus suis 
      bacterins is generally poor. We developed and tested the efficacy of a novel 
      ceftiofur-washed whole cell bacterin. Sixty-six, 2-week-old specific pathogen 
      free (SPF) pigs were randomly divided into 5 groups. Three groups were vaccinated 
      28 and 14 d prior to challenge. The 3 ceftiofur-washed whole cell bacterins each 
      contained 1 of 3 different adjuvants (Montanide ISA 25, Montanide ISA 50, and 
      Saponin). Pigs exhibiting severe central nervous system disease or severe joint 
      swelling and lameness were euthanized immediately and necropsied. All remaining 
      pigs were necropsied at 14 d post inoculation. The ceftiofur-washed whole cell S. 
      suis bacterin with Montanide ISA 50 adjuvant significantly (P < 0.05) reduced 
      bacteremia, meningitis, pneumonia, and mortality associated with S. suis 
      challenge. Further work on this novel approach to bacterin production is 
      warranted.
FAU - Pallares, Francisco J
AU  - Pallares FJ
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, College of 
      Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
FAU - Schmitt, Cameron S
AU  - Schmitt CS
FAU - Roth, James A
AU  - Roth JA
FAU - Evans, Richard B
AU  - Evans RB
FAU - Kinyon, Joann M
AU  - Kinyon JM
FAU - Halbur, Patrick G
AU  - Halbur PG
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Cephalosporins)
RN  - 83JL932I1C (ceftiofur)
SB  - IM
MH  - Animals
MH  - Bacteremia/prevention & control/*veterinary
MH  - *Bacterial Vaccines
MH  - *Cephalosporins
MH  - Specific Pathogen-Free Organisms
MH  - Streptococcal Infections/prevention & control/*veterinary
MH  - Streptococcus suis/*immunology
MH  - Swine
MH  - Swine Diseases/*prevention & control
PMC - PMC1142148
EDAT- 2004/09/09 05:00
MHDA- 2004/10/16 09:00
PMCR- 2004/10/01
CRDT- 2004/09/09 05:00
PHST- 2004/09/09 05:00 [pubmed]
PHST- 2004/10/16 09:00 [medline]
PHST- 2004/09/09 05:00 [entrez]
PHST- 2004/10/01 00:00 [pmc-release]
AID - pg236 [pii]
PST - ppublish
SO  - Can J Vet Res. 2004 Jul;68(3):236-40.