PMID- 15353845
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20190606
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 66
IP  - 8
DP  - 2004 Aug
TI  - Glucose uptake activity in murine red blood cells infected with Babesia microti 
      and Babesia rodhaini.
PG  - 945-9
AB  - The glucose uptake activity in Babesia rodhaini and B. microti - infected red 
      blood cell (IRBC) was investigated in mice using 2-deoxy-D-glucose (2DOG) and 
      L-glucose (L-Glc), a non-metabolizable analogue of D-glucose and 
      non-incorporative glucose to non-infected RBC (NRBC), respectively. The uptake 
      activities of both DOG and L-Glc were higher in IRBCs than those in NRBC. The 
      concentration dependent uptake of 2DOG and L-Glc in both IRBC revealed a linear 
      curve, indicating non-transporter mediated uptake. In addition, B. microti IRBC 
      showed higher 2DOG uptake than B. rodhaini IRBC, whereas no difference was 
      observed in L-Glc uptake. These results indicated that some new glucose uptake 
      system, at least two systems, developed in both IRBC. The new systems were sodium 
      independent, non-competitive to L-Glc, and sensitive to temperature. One of two 
      systems had no kinetical difference between B. rodhaini and B. microti IRBC, 
      however another one might have higher uptake activity in B. microti IRBC compared 
      to that in B. rodhaini IRBC.
FAU - Ohmori, Takashi
AU  - Ohmori T
AD  - Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural 
      and Life Sciences, The University of Tokyo, Japan.
FAU - Adachi, Keishi
AU  - Adachi K
FAU - Fukuda, Yoshimitsu
AU  - Fukuda Y
FAU - Tamahara, Satoshi
AU  - Tamahara S
FAU - Matsuki, Naoaki
AU  - Matsuki N
FAU - Ono, Kenichiro
AU  - Ono K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 9NEZ333N27 (Sodium)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - *Babesia microti
MH  - Erythrocytes/*metabolism/parasitology
MH  - Glucose/*pharmacokinetics
MH  - Isomerism
MH  - Kinetics
MH  - Mice/*metabolism/parasitology
MH  - Sodium/metabolism
MH  - Temperature
EDAT- 2004/09/09 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/09/09 05:00
PHST- 2004/09/09 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/09/09 05:00 [entrez]
AID - JST.JSTAGE/jvms/66.945 [pii]
AID - 10.1292/jvms.66.945 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2004 Aug;66(8):945-9. doi: 10.1292/jvms.66.945.