PMID- 15354311
OWN - NLM
STAT- MEDLINE
DCOM- 20050131
LR  - 20190917
IS  - 1472-6483 (Print)
IS  - 1472-6483 (Linking)
VI  - 9
IP  - 2
DP  - 2004 Aug
TI  - Preimplantation HLA typing and stem cell transplantation: report of International 
      Meeting, Cyprus, 27-8 March, 2004.
PG  - 205-9
AB  - There has been progress in the application of stem cell transplantation for the 
      treatment of an increasing number of severe congenital and acquired bone marrow 
      disorders that are currently restricted by the availability of human leukocyte 
      antigen(HLA)-matched related donors. Preimplantation HLA typing has recently been 
      introduced to improve the access to stem cell therapy for inherited bone marrow 
      failures, and its possible use for the treatment of common sporadic malignant and 
      non-malignant bone marrow disorders has also been explored. This paper describes 
      the current experience of preimplantation HLA typing, reviewed by the 
      International Meeting on the subject, which includes preimplantation HLA typing 
      in 147 cycles, 109 of which were carried out as part of preimplantation genetic 
      diagnosis (PGD) for Fanconi anaemia, thalassaemia, Wiscott-Aldrich syndrome, 
      hyperimmunoglobulin M syndrome, hypohidrotic ectodermal dysplasia with immune 
      deficiency, and X-linked adrenoleukodystrophy, and 38 for the sole purpose of HLA 
      typing for leukaemias and aplastic and Diamond-Blackfan anaemias. The applied 
      method resulted in the accurate pre-selection and transfer of HLA-matched 
      embryos, yielding 25 clinical pregnancies and the birth of 14 HLA-matched 
      children to the siblings who required stem cell transplantation.
FAU - Kuliev, Anver
AU  - Kuliev A
AD  - Reproductive Genetics Institute, Chicago, IL, USA. anverkuliev@hotmail.com
FAU - Verlinsky, Yury
AU  - Verlinsky Y
LA  - eng
PT  - Congress
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Bioethics
MH  - Female
MH  - Fertilization in Vitro/methods
MH  - HLA Antigens
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Living Donors
MH  - Models, Genetic
MH  - Polymorphism, Genetic
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
MH  - Siblings
MH  - Stem Cell Transplantation/*ethics/*methods
EDAT- 2004/09/10 05:00
MHDA- 2005/02/03 09:00
CRDT- 2004/09/10 05:00
PHST- 2004/09/10 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/09/10 05:00 [entrez]
AID - S1472-6483(10)62131-1 [pii]
AID - 10.1016/s1472-6483(10)62131-1 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2004 Aug;9(2):205-9. doi: 10.1016/s1472-6483(10)62131-1.