PMID- 15355466
OWN - NLM
STAT- MEDLINE
DCOM- 20050412
LR  - 20040909
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 10
DP  - 2004 Oct
TI  - Bronchial hyperresponsiveness in children with atopic rhinitis: a 7-year 
      follow-up.
PG  - 1074-9
AB  - BACKGROUND: A high prevalence of bronchial hyperresponsiveness (BHR) was found in 
      atopic subjects with rhinitis. Those subjects may be at higher risk for 
      developing bronchial asthma. We evaluated, in a 7-year follow-up, BHR and atopy 
      in a homogeneous population of nonasthmatic children with allergic rhinitis (AR), 
      and their role in asthma development. METHODS: Twenty-eight children (6-15 years) 
      with AR were studied. At enrollment (T(0)), skin tests, total serum IgE assay, 
      peak expiratory flow (PEF) monitoring and methacholine (Mch) bronchial challenge 
      were performed. BHR was computed as the Mch dose causing a 20% forced expiratory 
      volume (FEV)(1) fall (PD(20)FEV(1)) and as dose-response slope (D(RS)). Subjects 
      were reassessed after 7 years (T(1)) using the same criteria. RESULTS: At T(0), 
      13 children (46%), showing a PD(20)FEV(1) <1526 microg of Mch, had BHR (Mch+), 
      although PEF variability (PEFv) was within normal limits. None of the children 
      with negative methacholine test developed bronchial asthma after 7 years. Of the 
      13 Mch+, only two reported asthma symptoms after 7 years. No significant change 
      was seen in the other parameters of atopy considered. CONCLUSION: Children with 
      allergic rhinitis present a high prevalence of BHR. Nevertheless, their PEFv is 
      normal and the rate of asthma development low.
FAU - Cibella, F
AU  - Cibella F
AD  - Istituto di Biomedicina e Immunologia Molecolare del C.N.R., Palermo, Italy.
FAU - Cuttitta, G
AU  - Cuttitta G
FAU - La Grutta, S
AU  - La Grutta S
FAU - Hopps, M R
AU  - Hopps MR
FAU - Passalacqua, G
AU  - Passalacqua G
FAU - Pajno, G B
AU  - Pajno GB
FAU - Bonsignore, G
AU  - Bonsignore G
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Adolescent
MH  - Asthma/*etiology/physiopathology
MH  - Bronchial Hyperreactivity/complications/*physiopathology
MH  - Child
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/complications/physiopathology
MH  - Longitudinal Studies
MH  - Male
MH  - Pulmonary Ventilation
MH  - Rhinitis/complications/*physiopathology
EDAT- 2004/09/10 05:00
MHDA- 2005/04/13 09:00
CRDT- 2004/09/10 05:00
PHST- 2004/09/10 05:00 [pubmed]
PHST- 2005/04/13 09:00 [medline]
PHST- 2004/09/10 05:00 [entrez]
AID - ALL559 [pii]
AID - 10.1111/j.1398-9995.2004.00559.x [doi]
PST - ppublish
SO  - Allergy. 2004 Oct;59(10):1074-9. doi: 10.1111/j.1398-9995.2004.00559.x.