PMID- 15355616
OWN - NLM
STAT- MEDLINE
DCOM- 20090908
LR  - 20040909
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 16
IP  - 9
DP  - 2004 Sep
TI  - [Association between serum matrix metalloproteinase-3 concentration and the 
      promoter 5A/6A polymorphism in patients with coronary heart disease].
PG  - 536-9
AB  - OBJECTIVE: To investigate the association between serum matrix 
      metalloproteinase-3(MMP-3) concentrations and the promoter 5A/6A polymorphism in 
      patients with coronary heart disease (CHD). METHODS: The study enrolled 137 CHD 
      patients and 106 control subjects without CHD. The diagnosis of both groups were 
      confirmed by coronary artery angiography. One hundred and thirty-seven CHD 
      patients were divided into acute myocardial infarction (AMI)group, unstable 
      angina pectoris (UAP) group and stable angina (SA) group according to World 
      Health Organization criteria. Serum concentration of MMP-3 was measured by enzyme 
      linked immunoadsorbent assay (ELISA). MMP-3 promoter gene containing the 5A/6A 
      polymorphism was amplified by polymerase chain reaction (PCR). PCR products were 
      digested by Tth111 I and then were separated by electrophoresis on agarose gel. 
      RESULTS: The distribution of MMP-3 genotype was not significantly different 
      between CHD patients and controls, so was it between AMI patients and controls. 
      Serum MMP-3 level was significantly higher in AMI group than controls, UAP group 
      and SA group (56.815+/-38.932)microg/L, (39.149+/-24.155)microg/L, 
      (41.640+/-29.180)microg/L, (33.336+/-20.755)microg/L; P<0.01, P<0.05, P<0.01). 
      Serum MMP-3 levels were not significantly different among genotypes and among 
      controls, UAP and SA groups. No significantly differences in serum MMP-3 levels 
      were found among patients with different numbers of coronary arteries that were 
      involved in CHD. CONCLUSION: No marked association could be found between 5A/6A 
      polymorphism in MMP-3 gene and risk of CHD and AMI. Higher serum level of MMP-3 
      is strong associated with AMI, while not with number of coronary arteries that 
      are involved in CHD. These data suggest that MMP-3 is a useful marker for AMI, 
      and it might play an important role in the induction of disruption of 
      atherosclerosis plaque.
FAU - Gao, Bo
AU  - Gao B
AD  - Tianjin Tianhe Hospital, Tianjin 300050, China.
FAU - Li, Zhong-cheng
AU  - Li ZC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Coronary Disease/blood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood/*genetics
MH  - Middle Aged
MH  - Myocardial Infarction/blood/genetics
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
EDAT- 2004/09/10 05:00
MHDA- 2009/09/09 06:00
CRDT- 2004/09/10 05:00
PHST- 2004/09/10 05:00 [pubmed]
PHST- 2009/09/09 06:00 [medline]
PHST- 2004/09/10 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Sep;16(9):536-9.