PMID- 15355821
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20131121
IS  - 1302-8723 (Print)
IS  - 1302-8723 (Linking)
VI  - 4
IP  - 3
DP  - 2004 Sep
TI  - [Serum level of insulin-like growth factor-1 and insulin-like growth factor 
      binding protein-3 in acute coronary syndromes and relationship with prognosis].
PG  - 209-12
AB  - OBJECTIVE: The aim of the present study was to examine the levels of insulin-like 
      growth factor (IGF-I) and binding protein-3 (IGFBP-3) in acute coronary syndrome 
      (ACS) and their relationship with prognosis. METHODS: Thirty patients with ACS 
      (22 male, 8 female) were included in our study. Patient's population included 20 
      patients with ST elevation myocardial infarction (STEMI) and 10 with 
      non-ST-elevation ACS. Death, re-infarction, revascularization and malignant 
      arrhythmia were monitored during 3 months. Study group was compared with 20 
      healthy subjects (Controls). Blood samples were collected in the first 24 hours 
      and at the end of third month. Serum IGF-I and IGFBP-3 levels were determined by 
      radioimmunoassay method. RESULTS: We found decreased level of IGF-I only in the 
      STEMI group (105+/-84 ng/ml vs. 715+/-150 ng/ml, p<0.0001). There were no 
      significant differences in IGFBP-3 levels between two groups. Serum IGF-I levels 
      were significantly increased after 3rd month in the STEMI group (356+/-72 ng/ml 
      vs. 105+/-84 ng/ml, p=0.025). There was no relationship between IGF-I, IGFBP-3 
      levels and cardiovascular events occurred during 90 days of follow-up. 
      CONCLUSION: These data allows to suggest that significantly decreased level of 
      IGF-I in STEMI group of ACSs can be used as a marker of myocardial necrosis. 
      There was no relationship between IGF-I level and cardiovascular events occurred 
      in 90 days, so this parameter can not be used as a negative prognostic factor.
FAU - Sekuri, Cevad
AU  - Sekuri C
AD  - Department of Cardiology, Medical Faculty, Celal Bayar University, Manisa. 
      csekuri@hot.com
FAU - Arslan, Ozlem
AU  - Arslan O
FAU - Utuk, Ozan
AU  - Utuk O
FAU - Bayturan, Ozgur
AU  - Bayturan O
FAU - Onur, Ece
AU  - Onur E
FAU - Tezcan, Ugur Kemal
AU  - Tezcan UK
FAU - Tavli, Talat
AU  - Tavli T
LA  - tur
PT  - English Abstract
PT  - Journal Article
TT  - Akut Koroner Sendromlarda Insulin Benzeri Buyume Faktoru-I ve Insulin Benzeri 
      Buyume Faktoru Baglayici Protein-3 Duzeyleri ve Prognozla Iliskisi.
PL  - Turkey
TA  - Anadolu Kardiyol Derg
JT  - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
JID - 101095069
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Triglycerides)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/*mortality
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Triglycerides/blood
MH  - Turkey/epidemiology
EDAT- 2004/09/10 05:00
MHDA- 2004/11/17 09:00
CRDT- 2004/09/10 05:00
PHST- 2004/09/10 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/09/10 05:00 [entrez]
PST - ppublish
SO  - Anadolu Kardiyol Derg. 2004 Sep;4(3):209-12.