PMID- 15356423
OWN - NLM
STAT- MEDLINE
DCOM- 20041029
LR  - 20220129
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 24
IP  - 9
DP  - 2004 Sep
TI  - Relationship between flow-metabolism uncoupling and evolving axonal injury after 
      experimental traumatic brain injury.
PG  - 1025-36
AB  - Blood flow-metabolism uncoupling is a well-documented phenomenon after traumatic 
      brain injury, but little is known about the direct consequences for white matter. 
      The aim of this study was to quantitatively assess the topographic 
      interrelationship between local cerebral blood flow (LCBF) and glucose metabolism 
      (LCMRglc) after controlled cortical impact injury and to determine the degree of 
      correspondence with the evolving axonal injury. LCMRglc and LCBF measurements 
      were obtained at 3 hours in the same rat from 18F-fluorodeoxyglucose and 
      14C-iodoantipyrine coregistered autoradiographic images, and compared to the 
      density of damaged axonal profiles in adjacent sections and in an additional 
      group at 24 hours using beta-amyloid precursor protein (beta-APP) 
      immunohistochemistry. LCBF was significantly reduced over the ipsilateral 
      hemisphere by 48 +/- 15% compared with sham-controls, whereas LCMRglc was 
      unaffected, apart from foci of elevated LCMRglc in the contusion margin. 
      Flow-metabolism was uncoupled, indicated by a significant 2-fold elevation in the 
      LCMRglc/LCBF ratio within most ipsilateral structures. There was a significant 
      increase in beta-APP-stained axons from 3 to 24 hours, which was negatively 
      correlated with LCBF and positively correlated with the LCMRglc/LCBF ratio at 3 
      hours in the cingulum and corpus callosum. Our study indicates a possible 
      dependence of axonal outcome on flow-metabolism in the acute injury stage.
FAU - Chen, Szu-Fu
AU  - Chen SF
AD  - Academic Neurosurgery, Center for Brain Repair, University of Cambridge, Robinson 
      Way, UK.
FAU - Richards, Hugh K
AU  - Richards HK
FAU - Smielewski, Piotr
AU  - Smielewski P
FAU - Johnstrom, Peter
AU  - Johnstrom P
FAU - Salvador, Raymond
AU  - Salvador R
FAU - Pickard, John D
AU  - Pickard JD
FAU - Harris, Neil G
AU  - Harris NG
LA  - eng
GR  - G0001237/MRC_/Medical Research Council/United Kingdom
GR  - G9439390/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Carbon Radioisotopes)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - IY9XDZ35W2 (Glucose)
RN  - T3CHA1B51H (Antipyrine)
RN  - V30V6H1QX4 (iodoantipyrine)
SB  - IM
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Animals
MH  - Antipyrine/*analogs & derivatives/metabolism
MH  - Autoradiography
MH  - Axons/*metabolism/pathology
MH  - Brain Injuries/*metabolism/pathology/*physiopathology
MH  - Carbon Radioisotopes/metabolism
MH  - Cerebrovascular Circulation/*physiology
MH  - Fluorodeoxyglucose F18/metabolism
MH  - Glucose/*metabolism
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2004/09/10 05:00
MHDA- 2004/10/30 09:00
CRDT- 2004/09/10 05:00
PHST- 2004/09/10 05:00 [pubmed]
PHST- 2004/10/30 09:00 [medline]
PHST- 2004/09/10 05:00 [entrez]
AID - 00004647-200409000-00008 [pii]
AID - 10.1097/01.WCB.0000129415.34520.47 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2004 Sep;24(9):1025-36. doi: 
      10.1097/01.WCB.0000129415.34520.47.