PMID- 15357108
OWN - NLM
STAT- MEDLINE
DCOM- 20050105
LR  - 20190117
IS  - 1726-4901 (Print)
IS  - 1726-4901 (Linking)
VI  - 67
IP  - 5
DP  - 2004 May
TI  - The value of plasma levels of tumor necrosis factor-alpha and interleukin-6 in 
      predicting the severity and prognosis in patients with congestive heart failure.
PG  - 222-8
AB  - BACKGROUND: High plasma levels of pro-inflammatory cytokines play an important 
      role in the pathophysiology of congestive heart failure (CHF). Therefore, we 
      conducted a case-control study to determine the correlations between plasma 
      levels of cytokines, i.e., tumor necrosis factor-alpha (TNF-alpha) and 
      interleukin (IL)-6, and the severity and mortality in patients with CHF. METHODS: 
      One-hundred and 18 cases (62+/-15 years old) were classified into 3 groups: group 
      1 comprised 44 control cases with normal coronary arteriogram and left 
      ventriculography and without valvular disorders or cardiomyopathy; group 2 
      comprised of 37 cases with mild CHF in New York Heart Association (NYHA) 
      functional class (FC) II; group 3 had 37 cases with moderate/severe CHF in NYHA 
      FC III or IV. Pre-catheterization plasma levels of TNF-alpha and IL-6 along with 
      clinical and hemodynamic variables and follow-up data of cardiac death were 
      assessed. RESULTS: Patients of group 3 had smaller body mass index, lower 
      systolic and diastolic blood pressures, faster heart rates, higher left 
      ventricular end-diastolic pressure and lowered triglyceride levels than the 
      patients of groups 1 and 2. The plasma levels of TNF-alpha and IL-6 increased 
      significantly in patients of group 3 in comparison with patients of groups 1 and 
      2 (both p < 0.001). Over the following 1.5 years, 13 patients died. Univariate 
      analysis identified the following variables to be associated with poor prognosis: 
      NYHA FC (p < 0.001), plasma TNF-alpha (p = 0.013), plasma IL-6 (p < 0.001), 
      systolic blood pressure (p = 0.001), heart rate (p = 0.045) and left ventricular 
      end-diastolic pressure (p = 0.021). Multivariate Cox regression analysis 
      identified the independent predictors of cardiac death as FC (p = 0.007) and 
      plasma IL-6 (p = 0.021). CONCLUSIONS: Our findings indicate that the plasma 
      levels of IL-6 and TNF-alpha and especially the former, is a useful marker to 
      correlate the progression of severity and late cardiac death in patients with 
      CHF.
FAU - Pan, Ju-Pin
AU  - Pan JP
AD  - Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. 
      jppan@vghtpe.gov.tw
FAU - Liu, Tu-Ying
AU  - Liu TY
FAU - Chiang, Shu-Chiung
AU  - Chiang SC
FAU - Lin, Yung-Kuo
AU  - Lin YK
FAU - Chou, Chia-Yea
AU  - Chou CY
FAU - Chan, Wan-leong
AU  - Chan WL
FAU - Lai, Shiau-Ting
AU  - Lai ST
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Female
MH  - Heart Failure/*blood/mortality/pathology
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Severity of Illness Index
MH  - Survival Rate
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2004/09/11 05:00
MHDA- 2005/01/06 09:00
CRDT- 2004/09/11 05:00
PHST- 2004/09/11 05:00 [pubmed]
PHST- 2005/01/06 09:00 [medline]
PHST- 2004/09/11 05:00 [entrez]
PST - ppublish
SO  - J Chin Med Assoc. 2004 May;67(5):222-8.