PMID- 1535772
OWN - NLM
STAT- MEDLINE
DCOM- 19920805
LR  - 20041117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 12
IP  - 3
DP  - 1992 May-Jun
TI  - Relationships for recombinant interleukin-2-stimulated mixed lymphocyte tumor 
      extract reaction between peripheral blood lymphocytes and regional node 
      lymphocytes in gastric cancer patients.
PG  - 927-32
AB  - To investigate the relationship between "systemic" antitumor immunity and "local" 
      antitumor immunity with respect to the histopathological stage of gastric cancer, 
      interleukin-2 stimulated mixed lymphocyte tumor extract reactions (ILS-MLTR) of 
      peripheral blood lymphocytes (PBL) and regional node lymphocytes (RNL) were 
      evaluated in 59 gastric cancer patients. ILS-MLTRs of both PBL and RNL decreased 
      with the advance of cancer stage, but ILS-MLTRs of PBL were always lower than 
      those of RNL. Positive correlations in MLTR between PBL and RNL were found in 
      patients with depth of invasion to muscularis propria and serosa and peritoneal 
      dissemination. Inverse correlations between PBL and RNL were noted in patients 
      with stage IV and distant nodal involvement. These results suggest that 
      variations in the anticancer immunities might be effectively managed by an 
      immunotherapy which is designed according to the responsiveness in the immune 
      parameter ILS-MLTR.
FAU - Tseng, C C
AU  - Tseng CC
AD  - First Department of Surgery, Kyoto University Faculty of Medicine, Japan.
FAU - Nio, Y
AU  - Nio Y
FAU - Tsubono, M
AU  - Tsubono M
FAU - Fukumoto, M
AU  - Fukumoto M
FAU - Tobe, T
AU  - Tobe T
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Interleukin-2)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tissue Extracts)
SB  - IM
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Interleukin-2/*pharmacology
MH  - Lymph Nodes/*immunology/pathology
MH  - Lymphocyte Culture Test, Mixed
MH  - Lymphocytes/drug effects/*immunology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Recombinant Proteins/pharmacology
MH  - Stomach Neoplasms/*immunology/pathology
MH  - Tissue Extracts/immunology
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1992 May-Jun;12(3):927-32.