PMID- 15359912
OWN - NLM
STAT- MEDLINE
DCOM- 20041102
LR  - 20151119
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 45
IP  - 7
DP  - 2004 Jul
TI  - [Clinical significance of detecting strong bcl-2 protein expression with flow 
      cytometry in follicular lymphoma].
PG  - 530-8
AB  - The expression of cell surface antigens and bcl-2 protein was examined with flow 
      cytometry in 30 lymphoma samples including 28 lymph nodes and others, from 
      January, 2001 to May, 2003. Cases studied included the following: follicular 
      lymphoma (FL), 11; diffuse large B-cell lymphoma (DLBCL), 12; diffuse small 
      B-cell lymphoma, 1; mantle cell lymphoma, 1; MALT lymphoma, 1; precursor-B 
      lymphoblastic lymphoma, 1; T-lymphoblastic lymphoma, 1; blastic NK-cell lymphoma, 
      1; and unknown, 1. In addition, cytogenetic analysis, fluorescence in situ 
      hybridization (FISH), and a real-time polymerase chain reaction assay were 
      performed. Strong bcl-2 expression was observed in 91% of FL, and 17% of DLBCL. 
      On the other hand, strong bcl-2 expression was found in all 9 cases of FL with 
      t(14;18), all two cases of DLBCL with t(14;18), one unknown case with t(14;18), 
      and one FL case with t(11;14). Our results support that strong bcl-2 expression 
      as demonstrated with flow cytometry is correlated with FL (p<0.0001), and 
      lymphomas with the t(14;18) (p<0.0001).
FAU - Kobayashi, Shoichi
AU  - Kobayashi S
AD  - Second Division of Clinical Laboratory, Kanagawa Cancer Center.
FAU - Motomura, Shigeki
AU  - Motomura S
FAU - Kishi, Yoko
AU  - Kishi Y
FAU - Hashimoto, Chizuko
AU  - Hashimoto C
FAU - Maruta, Atuo
AU  - Maruta A
FAU - Kodama, Fumio
AU  - Kodama F
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD/analysis
MH  - Biomarkers, Tumor
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 18
MH  - Female
MH  - *Flow Cytometry
MH  - Humans
MH  - Lymphoma, Follicular/*diagnosis/genetics
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-bcl-2/*analysis
MH  - Translocation, Genetic
EDAT- 2004/09/14 05:00
MHDA- 2004/11/04 09:00
CRDT- 2004/09/14 05:00
PHST- 2004/09/14 05:00 [pubmed]
PHST- 2004/11/04 09:00 [medline]
PHST- 2004/09/14 05:00 [entrez]
PST - ppublish
SO  - Rinsho Ketsueki. 2004 Jul;45(7):530-8.