PMID- 15360269
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20131121
IS  - 1525-7797 (Print)
IS  - 1525-7797 (Linking)
VI  - 5
IP  - 5
DP  - 2004 Sep-Oct
TI  - Artificial receptor-attached amphiphilic copolymer for barbiturate binding in 
      aqueous media.
PG  - 1647-52
AB  - A water-soluble self-associating amphiphilic copolymer was employed to provide a 
      microenvironment for the solvation of a hydrogen-bonding barbiturate artificial 
      receptor, to facilitate molecular recognition in water. The receptor-attached 
      amphiphilic polymer (RP) was synthesized through random copolymerization of 3% 
      (mol) barbiturate receptor-monomer, 70% (mol) 3-sulfopropyl methacrylate, and 27% 
      (mol) n-dodecyl acrylate. Difference UV spectra of pH 6.5 aqueous solutions of 
      phenobarbital and receptor-polymer (RP) gave peaks and valleys at 272 and 301 nm 
      respectively, consistent with binding characteristics of monomeric barbiturate 
      receptors in chloroform. Specific association between phenobarbital and the 
      receptor-polymer was further indicated based on investigations of a receptor-free 
      control polymer (CP) of similar polar/nonpolar monomer ratio. Micellar 
      electrokinetic chromatography was applied for studying polymer-phenobarbital 
      association, by capillary electrophoresis.
FAU - Loizidou, Eriketi
AU  - Loizidou E
AD  - Department of Chemistry, San Diego State University, 5500 Campanile Drive, 
      California 92182, USA. loizidou@rohan.sdsu.edu
FAU - Zeinalipour-Yazdi, Constantinos
AU  - Zeinalipour-Yazdi C
FAU - Sun, Lifang
AU  - Sun L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Barbiturates)
RN  - 0 (Polymers)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Surface-Active Agents)
RN  - 0 (barbiturate receptor)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Barbiturates/analysis/chemistry/*metabolism
MH  - Polymers/analysis/chemistry/*metabolism
MH  - Protein Binding/physiology
MH  - Receptors, GABA-A/analysis/chemistry/*metabolism
MH  - Spectrophotometry, Ultraviolet/methods
MH  - Surface-Active Agents/analysis/chemistry/*metabolism
MH  - Water/analysis
EDAT- 2004/09/14 05:00
MHDA- 2005/02/23 09:00
CRDT- 2004/09/14 05:00
PHST- 2004/09/14 05:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/09/14 05:00 [entrez]
AID - 10.1021/bm0497320 [doi]
PST - ppublish
SO  - Biomacromolecules. 2004 Sep-Oct;5(5):1647-52. doi: 10.1021/bm0497320.