PMID- 15361131 OWN - NLM STAT- MEDLINE DCOM- 20050224 LR - 20081121 IS - 0001-2815 (Print) IS - 0001-2815 (Linking) VI - 64 IP - 4 DP - 2004 Oct TI - Identification of three novel HLA class I alleles: HLA-B*3928, HLA-B*400104 and HLA-B*4437. PG - 509-11 AB - Three new human leukocyte antigen (HLA) class I alleles have been identified in the Tissue Typing Laboratory in Sydney, Australia. Sequence analysis of exon 2 and exon 3 of the HLA-B gene revealed the novel polymorphism. A silent substitution of C to T at nucleotide position 369 has been identified for the HLA-B*400104 allele when compared to the closest matched allele, HLA-B*400101. The HLA-B*3928 allele was identified with a nucleotide substitution of G to C at position 362 when compared to the closest matched allele, HLA-B*390101, resulting in an amino acid substitution of Arginine to Threonine. A nucleotide substitution of C to G at position 572 resulting in the amino acid change Serine to Tryptophan was identified in the new allele HLA-B*4437, when compared to the closest matched allele HLA-B*440301. Both amino acid substitutions implicate a different specificity and affinity of antigen binding for the alleles HLA-B*3928 and HLA-B*4437. FAU - Velickovic, Z M AU - Velickovic ZM AD - Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, Sydney, Australia. FAU - Dodd, R AU - Dodd R FAU - Velickovic, M AU - Velickovic M FAU - Hersee, J AU - Hersee J FAU - Le, T AU - Le T FAU - Taverniti, A AU - Taverniti A FAU - Wallace, R AU - Wallace R FAU - Dunckley, H AU - Dunckley H LA - eng PT - Journal Article PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (DNA Probes, HLA) RN - 0 (HLA-B Antigens) SB - IM MH - *Alleles MH - Amino Acid Substitution/genetics MH - Base Sequence MH - DNA Probes, HLA/*genetics MH - Exons/genetics MH - *Genetic Variation MH - HLA-B Antigens/*genetics MH - Humans MH - Molecular Sequence Data MH - Sequence Analysis, DNA EDAT- 2004/09/14 05:00 MHDA- 2005/02/25 09:00 CRDT- 2004/09/14 05:00 PHST- 2004/09/14 05:00 [pubmed] PHST- 2005/02/25 09:00 [medline] PHST- 2004/09/14 05:00 [entrez] AID - TAN288 [pii] AID - 10.1111/j.1399-0039.2004.00288.x [doi] PST - ppublish SO - Tissue Antigens. 2004 Oct;64(4):509-11. doi: 10.1111/j.1399-0039.2004.00288.x.