PMID- 15361701
OWN - NLM
STAT- MEDLINE
DCOM- 20050415
LR  - 20151119
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 98
IP  - 1
DP  - 2004
TI  - CD68 and MCP-1/CCR2 expression of initial biopsies reflect the outcomes of 
      membranous nephropathy.
PG  - c25-34
AB  - BACKGROUND: A considerable diversity of prognosis is seen with idiopathic 
      membranous nephropathy (IMN). The initial factors affecting long-term outcome 
      remain unclear. METHODS: We studied retrospectively 30 patients with IMN who had 
      been followed up for at least 5 years, or until end-stage renal failure (ESRF). 
      We analyzed the prognostic factors of ESRF in the first renal biopsies; these 
      factors included presence of tubulointerstitial lesions and foam cells, as well 
      as expression of CD68, monocyte chemoattractant protein-1 (MCP-1), its cognate 
      receptor chemokine receptor 2 (CCR2) and alpha-smooth muscle actin. RESULTS: The 
      patients who developed ESRF showed higher percentages of glomerular segmental 
      sclerosis, interstitial MCP-1 expression, CCR2- or CD68-positive 
      monocyte/macrophages and foam cells in the interstitium, and these proved on 
      multivariate analysis to be independent risk factors for ESRF. Finally, ESRF was 
      characterized by the presence of ten interstitial CD68-positive cells per visual 
      field at 200x magnification (hazard ratio 4.096, CI 1.271-15.029, p < 0.001). 
      CONCLUSIONS: Our results suggested that an interstitial infiltration of 
      CD68-positive cells accompanied by MCP-1/CCR2 expression is the most significant 
      indicator of ESRF in IMN.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Yoshimoto, Keiichi
AU  - Yoshimoto K
AD  - Department of Gastroenterology and Nephrology and Division of Blood Purification, 
      Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. 
      dialysis@medf.m.kanazawa-u.ac.jp
FAU - Wada, Takashi
AU  - Wada T
FAU - Furuichi, Kengo
AU  - Furuichi K
FAU - Sakai, Norihiko
AU  - Sakai N
FAU - Iwata, Yasunori
AU  - Iwata Y
FAU - Yokoyama, Hitoshi
AU  - Yokoyama H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Antigens, CD/*analysis
MH  - Antigens, Differentiation, Myelomonocytic/*analysis
MH  - Biomarkers/analysis
MH  - Biopsy
MH  - Chemokine CCL2/*analysis
MH  - Fibrosis
MH  - Foam Cells/pathology
MH  - Glomerulonephritis, Membranous/*pathology
MH  - Kidney/*chemistry/*pathology
MH  - Kidney Glomerulus/chemistry/ultrastructure
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/*analysis
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2004/09/14 05:00
MHDA- 2005/04/16 09:00
CRDT- 2004/09/14 05:00
PHST- 2003/08/18 00:00 [received]
PHST- 2004/04/02 00:00 [accepted]
PHST- 2004/09/14 05:00 [pubmed]
PHST- 2005/04/16 09:00 [medline]
PHST- 2004/09/14 05:00 [entrez]
AID - 79924 [pii]
AID - 10.1159/000079924 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2004;98(1):c25-34. doi: 10.1159/000079924.