PMID- 15362688
OWN - NLM
STAT- MEDLINE
DCOM- 20050812
LR  - 20140625
VI  - 18
IP  - 2
DP  - 2004 Feb
TI  - [Relationship among expression of the VEGF gene and MVD with cervical lymph nodes 
      metastasis in laryngeal squamous cell carcinoma].
PG  - 100-2
AB  - OBJECTIVE: To study the relation among the expression of the vascular endothelial 
      growth factor (VEGF) gene and microvessel Density (MVD) with cervical lymph nodes 
      metastasis in laryngeal squamous cell carcinoma (LSCC). METHOD: Appling 
      semi-RT-PCR technique and immunohistochemistry detected the expression of 
      VEGFmRNA and protein and MVD count in 60 cases with LSCC. RESULT: The expression 
      of VEGF and MVD was both higher either at molecular level or at the protein level 
      in the group with cervical lymph nodes metastasis than the those with cervical 
      lymph nodes-negative metastasis. The overexpression of VEGF had a positive 
      correlation with the higher MVD count and were both related to cervical lymph 
      nodes metastasis in the 60 cases with LSCC. CONCLUSION: There was a significant 
      correlation between the expression of VEGF and MVD, which suggested that the 
      overexpression of VEGF was essential to microangiogenesis of LSCC, and the both 
      were related to cervical lymph nodes metastasis and would become a biologic 
      indexes to prognosis of LSCC. Antiangiogenic therapy with specific antibodies to 
      VEGF leads to inhibit angiogenesis and prevent tumor from growth and metastasis, 
      which might have a bright future in clinical application.
FAU - Wang, Zhanping
AU  - Wang Z
AD  - Department of Otolaryngology, Benxi Central Hospital, Benxi, 117000, China.
FAU - Ji, Wenyue
AU  - Ji W
FAU - Tang, Qiaofei
AU  - Tang Q
FAU - Pan, Zimin
AU  - Pan Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/blood supply/*metabolism/secondary
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/blood supply/*metabolism/pathology
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neck
MH  - *Neovascularization, Pathologic
MH  - Vascular Endothelial Growth Factors/*biosynthesis/genetics
EDAT- 2004/09/15 05:00
MHDA- 2005/08/13 09:00
CRDT- 2004/09/15 05:00
PHST- 2004/09/15 05:00 [pubmed]
PHST- 2005/08/13 09:00 [medline]
PHST- 2004/09/15 05:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 Feb;18(2):100-2.