PMID- 15363505
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20181130
IS  - 0378-5173 (Print)
IS  - 0378-5173 (Linking)
VI  - 283
IP  - 1-2
DP  - 2004 Sep 28
TI  - Effect of plasticization on heparin release from biodegradable matrices.
PG  - 89-96
AB  - Heparin-loaded polymer films of poly-L-lactide (PLLA) and 
      poly-L-lactide-co-glycolide (PLLGA) as well as poly-DL-lactide-co-glycolide 
      (PLGA) were produced. A plasticizer, PEG, was added to the polymers. It was found 
      that the release profile in general consisted of a burst effect, a 
      diffusion-controlled phase and a degradation-controlled phase. The plasticizer 
      accelerated the onset of degradation in all cases, but its effect on the release 
      profile differed significantly depending on the polymer. The plasticizer 
      depressed the burst effect for PLLA, and accelerated the kinetics of the 
      diffusion-controlled phase. For the PLLGA 80/20, however, the plasticizer had no 
      significant effect on the release profile or kinetics. We explain these 
      observations in terms of hydrophilicity and crystallinity effects.
FAU - Tan, L P
AU  - Tan LP
AD  - School of Materials Engineering, Nanyang Technological University, N4.1-1-30 
      Nanyang Avenue, Singapore 639798, Singapore.
FAU - Venkatraman, S S
AU  - Venkatraman SS
FAU - Sung, P F
AU  - Sung PF
FAU - Wang, X T
AU  - Wang XT
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Anticoagulants)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Plasticizers)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - *Absorbable Implants
MH  - Anticoagulants/*administration & dosage
MH  - *Biocompatible Materials
MH  - Heparin/*administration & dosage
MH  - Lactic Acid
MH  - *Plasticizers
MH  - Polyesters
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers
MH  - Stents
MH  - *Technology, Pharmaceutical
EDAT- 2004/09/15 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/09/15 05:00
PHST- 2004/03/18 00:00 [received]
PHST- 2004/06/11 00:00 [revised]
PHST- 2004/06/25 00:00 [accepted]
PHST- 2004/09/15 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/09/15 05:00 [entrez]
AID - S0378-5173(04)00420-X [pii]
AID - 10.1016/j.ijpharm.2004.06.022 [doi]
PST - ppublish
SO  - Int J Pharm. 2004 Sep 28;283(1-2):89-96. doi: 10.1016/j.ijpharm.2004.06.022.