PMID- 15363581
OWN - NLM
STAT- MEDLINE
DCOM- 20041119
LR  - 20141120
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 203
IP  - 1-3
DP  - 2004 Oct 15
TI  - Genotoxic effects on human spermatozoa among pesticide factory workers exposed to 
      fenvalerate.
PG  - 49-60
AB  - Fenvalerate, a synthetic pyrethroid insecticide, is widely produced and used 
      worldwide. To explore fenvalerate-induced genotoxic effects, particularly 
      numerical chromosome aberration (CA), we firstly examined conventional semen 
      parameters, the progression and motion parameters of the spermatozoa among 12 
      fenvalerate-exposed workers and 30 donors of the internal and external control 
      groups. Then numerical CA of chromosome X, Y and 18 were investigated by 
      multicolor fluorescence in situ hybridization (FISH). The results showed the 
      significant differences in the percentage of sperm abnormality between 
      fenvalerate-exposed group and the external control group (P = 0.024). In 
      aneuploid parameters, the frequency (mean +/- S.D.) of sex chromosome disomy was 
      0.742 +/- 0.131% in fenvalerate-exposed group, which was significantly higher 
      than those in the internal (0.563 +/- 0.135%) and external control group (0.386 
      +/- 0.140%) (P < 0.01), and the frequency of chromosome 18 disomy in 
      fenvalerate-exposed group (0.326 +/- 0.069%) was significantly higher than those 
      in the internal and external control groups (0.195 +/- 0.094% and 0.124 +/- 
      0.068%), respectively (P < 0.01). We also found the nullisomies of sex 
      chromosomes and chromosome 18 were significantly higher than those in the 
      external control group and two control groups, respectively (P < 0.01). The 
      frequencies of aneuploidy and numerical CA we detected also showed significant 
      differences between exposed group and control groups (P < 0.05 and/or P < 0.01). 
      Moreover, we found the positive correlation not only between nullisomic 
      frequencies of these chromosomes and numerical CA rate (r > 0.70, P < 0.01) but 
      also between disomic frequency of sex chromosomes, aneuploidy rate and sperm 
      abnormality in all donors (r = 0.530 and r = 0.536, P < 0.01). Our findings 
      suggest that fenvalerate or its metabolites induced morphologic abnormality and 
      genotoxic defects of spermatozoa among fenvalerate-exposed workers by causing 
      numerical CA in spermatogenesis as a special and potential genotoxic agent.
FAU - Xia, Yankai
AU  - Xia Y
AD  - Institute of Toxicology, Nanjing Medical University, 210029, China.
FAU - Bian, Qian
AU  - Bian Q
FAU - Xu, Lichun
AU  - Xu L
FAU - Cheng, Senping
AU  - Cheng S
FAU - Song, Lin
AU  - Song L
FAU - Liu, Jiayin
AU  - Liu J
FAU - Wu, Wei
AU  - Wu W
FAU - Wang, Shoulin
AU  - Wang S
FAU - Wang, Xinru
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (DNA Probes)
RN  - 0 (Insecticides)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - Z6MXZ39302 (fenvalerate)
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - Chromosome Aberrations/drug effects
MH  - Chromosomes, Human, Pair 18/drug effects/ultrastructure
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization
MH  - In Vitro Techniques
MH  - Insecticides/*toxicity
MH  - Male
MH  - Nitriles
MH  - Occupational Exposure/*adverse effects
MH  - Pyrethrins/*toxicity
MH  - Sex Chromosomes/drug effects/ultrastructure
MH  - Sperm Motility/drug effects
MH  - Spermatozoa/*drug effects
EDAT- 2004/09/15 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/15 05:00
PHST- 2004/04/04 00:00 [received]
PHST- 2004/05/21 00:00 [revised]
PHST- 2004/05/24 00:00 [accepted]
PHST- 2004/09/15 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/15 05:00 [entrez]
AID - S0300483X04003051 [pii]
AID - 10.1016/j.tox.2004.05.018 [doi]
PST - ppublish
SO  - Toxicology. 2004 Oct 15;203(1-3):49-60. doi: 10.1016/j.tox.2004.05.018.