PMID- 15364842
OWN - NLM
STAT- MEDLINE
DCOM- 20050425
LR  - 20191210
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 110
IP  - 11 Suppl 1
DP  - 2004 Sep 14
TI  - Prospectively randomized evaluation of stented xenograft hemodynamic function in 
      the aortic position.
PG  - II74-8
AB  - BACKGROUND: Standard stented aortic xenograft valves have not yet been compared 
      regarding their hemodynamic function using a stratified intraoperative 
      randomization protocol. METHODS AND RESULTS: 100 patients were prospectively 
      included after intraoperative metric sizing of the decalcified aortic annulus. 
      They received Mosaic (M) or Perimount (P) aortic valve replacement. Patient age 
      was 73+/-5 years, 51 were female, and New York Heart Association (NYHA) 
      functional class was 2.8+/-0.5. The 21-mm annulus group consisted of 5 (M)/7 (P) 
      patients, the 23-mm annulus group of 20 (M)/20 (P), the 25-mm annulus group of 18 
      (M)/19 (P), and the 27-mm annulus group of 4 (M)/7 (P) patients, respectively. 
      Hemodynamic function was evaluated using transthoracic echocardiography before 
      discharge and at follow-up (438+/-352 days). Surgery was uncomplicated in all 
      patients. Labeled valve sizes were 0.93 (M) and 1.05 (P) mm smaller than the 
      annulus diameters (p=NS). In-hospital mortality was 5%, all nonvalve-related. 
      Transvalvular blood flow velocities and transvalvular pressure gradients were 
      significantly lower in the 25 P versus the 25 M group at baseline and in the 23 P 
      and 25 P groups at follow-up. There was a significant regression of left 
      ventricular mass index in all patients at follow-up. However, left ventricular 
      mass regression was more pronounced after P aortic valve replacement. 
      CONCLUSIONS: Labeled sizes of prosthetic heart valves implanted are smaller than 
      the true aortic annulus. Both standard aortic xenografts compared in this 
      prospectively randomized trial provide a sufficient hemodynamic and functional 
      outcome.
FAU - Walther, Thomas
AU  - Walther T
AD  - Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Germany. 
      walt@medizin.uni-leipzig.de
FAU - Lehmann, Sven
AU  - Lehmann S
FAU - Falk, Volkmar
AU  - Falk V
FAU - Metz, Sebastian
AU  - Metz S
FAU - Doll, Nicolas
AU  - Doll N
FAU - Rastan, Ardawan
AU  - Rastan A
FAU - Viehweg, Marika
AU  - Viehweg M
FAU - Richter, Markus
AU  - Richter M
FAU - Gummert, Jan
AU  - Gummert J
FAU - Mohr, Friedrich W
AU  - Mohr FW
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Detergents)
RN  - 0 (Surface-Active Agents)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Aortic Valve/*surgery
MH  - Aortic Valve Stenosis/*surgery
MH  - *Bioprosthesis/standards
MH  - Body Surface Area
MH  - Calcinosis/prevention & control
MH  - Cattle
MH  - Coated Materials, Biocompatible
MH  - Death, Sudden, Cardiac/epidemiology
MH  - Detergents/administration & dosage
MH  - Equipment Design
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis/standards
MH  - *Hemodynamics
MH  - Hospital Mortality
MH  - Humans
MH  - Hypertrophy, Left Ventricular/etiology/surgery
MH  - Infections/epidemiology
MH  - Male
MH  - Multiple Organ Failure/epidemiology
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - *Stents
MH  - Stroke/epidemiology
MH  - Surface-Active Agents/administration & dosage
MH  - Sus scrofa
MH  - Treatment Outcome
EDAT- 2004/09/15 05:00
MHDA- 2005/04/26 09:00
CRDT- 2004/09/15 05:00
PHST- 2004/09/15 05:00 [pubmed]
PHST- 2005/04/26 09:00 [medline]
PHST- 2004/09/15 05:00 [entrez]
AID - 110/11_suppl_1/II-74 [pii]
AID - 10.1161/01.CIR.0000138947.63799.89 [doi]
PST - ppublish
SO  - Circulation. 2004 Sep 14;110(11 Suppl 1):II74-8. doi: 
      10.1161/01.CIR.0000138947.63799.89.