PMID- 1536582
OWN - NLM
STAT- MEDLINE
DCOM- 19920323
LR  - 20190501
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Print)
IS  - 0003-9888 (Linking)
VI  - 67
IP  - 1 Spec No
DP  - 1992 Jan
TI  - Treatment of severe persistent pulmonary hypertension of the newborn with 
      magnesium sulphate.
PG  - 31-5
AB  - Eight of nine newborn infants with severe persistent pulmonary hypertension of 
      the newborn (PPHN), and a predicted mortality of 100%, and one infant with a 
      predicted mortality greater than 94% based on alveolar-arterial oxygen tension 
      difference [A-a)DO2) were treated with magnesium sulphate (MgSO4) as a life 
      saving therapy after they failed to improve with conventional treatment. 
      Magnesium at high serum concentrations decreases pulmonary pressures and is a 
      muscle relaxant and sedative. Diluted MgSO4.7H2O solution (200 mg/kg) was given 
      intravenously over 20-30 minutes. No changes in the treatment were made after 
      MgSO4. Mean serum magnesium concentration was maintained between 2.88 and 5.67 
      mmol/l by continuous intravenous infusion (six infants). Baseline arterial oxygen 
      tension (PaO2) and haemoglobin oxygen saturation had mean (SD) values of 4.66 
      (1.8) kPa and 60.4 (29.7)% respectively, which started to increase one hour after 
      MgSO4 infusion, and increased significantly at six hours to 12.04 (7.07) kPa and 
      91.8 (10.88)% respectively. Arterial carbon dioxide tension (PaCO2) decreased and 
      pH increased significantly after one hour compared with the baseline value. PaO2 
      increases are probably secondary to a decrease in pulmonary vascular resistance 
      and pressure, decrease in a right to left shunt, better ventilation:perfusion 
      ratio, and PaCO2 decrease and pH rise. Seven infants survived (77.8%). These 
      results demonstrate the beneficial effect of magnesium in the management of PPHN 
      when other accepted treatment fails, is contraindicated, or not available.
FAU - Abu-Osba, Y K
AU  - Abu-Osba YK
AD  - Paediatric Department, King Faisal Specialist Hospital and Research Centre, 
      Riyadh, Kingdom of Saudi Arabia.
FAU - Galal, O
AU  - Galal O
FAU - Manasra, K
AU  - Manasra K
FAU - Rejjal, A
AU  - Rejjal A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 7487-88-9 (Magnesium Sulfate)
RN  - I38ZP9992A (Magnesium)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Magnesium/blood
MH  - Magnesium Sulfate/*therapeutic use
MH  - Oxygen/blood
MH  - Persistent Fetal Circulation Syndrome/blood/*drug therapy
PMC - PMC1590342
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
PMCR- 1992/01/01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PHST- 1992/01/01 00:00 [pmc-release]
AID - 10.1136/adc.67.1_spec_no.31 [doi]
PST - ppublish
SO  - Arch Dis Child. 1992 Jan;67(1 Spec No):31-5. doi: 10.1136/adc.67.1_spec_no.31.