PMID- 15367184
OWN - NLM
STAT- MEDLINE
DCOM- 20041115
LR  - 20220330
IS  - 0303-6979 (Print)
IS  - 0303-6979 (Linking)
VI  - 31
IP  - 10
DP  - 2004 Oct
TI  - Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in 
      patients with generalized aggressive periodontitis.
PG  - 829-34
AB  - BACKGROUND: Local and systemic inflammatory and immune mechanisms may be 
      implicated in the pathogenesis of the aggressive forms of periodontal disease. 
      Chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on 
      activation, normal T cells expressed and secreted RANTES (regulated on 
      activation, normal T cells expressed and secreted), are involved in the 
      activation and recruitment of inflammatory and immune cells to the infected sites 
      and thereby mediating a variety of pathophysiological conditions. The aim of the 
      present study was to examine the gingival crevicular fluid (GCF) levels of MCP-1 
      and RANTES in patients with generalized agressive periodontitis (G-AgP). METHODS: 
      MCP-1 and RANTES levels were investigated in GCF samples of 10 patients with 
      G-AgP and 10 periodontally healthy subjects. Periodontal status was evaluated by 
      measuring probing depth, clinical attachment loss, presence of bleeding on 
      probing and plaque. In the G-AgP group, GCF samples were collected from the two 
      approximal sites; from one single-rooted tooth and from one first molar tooth 
      with > or =6 mm probing depth. In the healthy group, GCF samples were collected 
      from one of the single-rooted teeth. GCF MCP-1 and RANTES levels were quantified 
      by enzyme immunoassay. RESULTS: The G-AgP patients had significantly higher GCF 
      MCP-1 and RANTES levels compared to the healthy group (p<0.05). GCF MCP-1 and 
      RANTES levels were positively correlated with both probing depth and clinical 
      attachment loss (p<0.05). There was no correlation between GCF MCP-1 and RANTES 
      levels and the percentage of sites with bleeding (p>0.05). CONCLUSIONS: The 
      results of the present study suggest that MCP-1 and RANTES could play key roles 
      in both activation and recruitment of inflammatory and immune cells in 
      periodontal environment of G-AgP patients. In conclusion, these CC chemokines may 
      be considered in the biological mechanism underlying the pathogenesis and 
      progression of G-AgP.
CI  - Copyright Blackwell Munksgaard, 2004
FAU - Emingil, Gulnur
AU  - Emingil G
AD  - Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey. 
      gemingil@yahoo.com
FAU - Atilla, Gul
AU  - Atilla G
FAU - Huseyinov, Afig
AU  - Huseyinov A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*analysis
MH  - Chemokine CCL5/*analysis
MH  - Female
MH  - Gingival Crevicular Fluid/*chemistry/immunology
MH  - Humans
MH  - Male
MH  - Periodontitis/*immunology
MH  - Statistics, Nonparametric
EDAT- 2004/09/16 05:00
MHDA- 2004/11/16 09:00
CRDT- 2004/09/16 05:00
PHST- 2004/09/16 05:00 [pubmed]
PHST- 2004/11/16 09:00 [medline]
PHST- 2004/09/16 05:00 [entrez]
AID - CPE584 [pii]
AID - 10.1111/j.1600-051X.2004.00584.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2004 Oct;31(10):829-34. doi: 
      10.1111/j.1600-051X.2004.00584.x.