PMID- 15367282
OWN - NLM
STAT- MEDLINE
DCOM- 20050209
LR  - 20061115
IS  - 1397-3142 (Print)
IS  - 1397-3142 (Linking)
VI  - 8
IP  - 5
DP  - 2004 Oct
TI  - Risk factors in pediatric stem cell transplantation for leukemia.
PG  - 464-74
AB  - To investigate which factors impact on survival, relapse, relapse free survival, 
      transplant-related mortality (TRM) and graft-versus-host disease (GVHD) in 
      children who undergo allogeneic stem cell transplantation, we included all 181 
      children transplanted due to leukemia at our unit. At the end of follow up 54% of 
      the patients were alive, 27% had died due to relapse while 19% had died of other 
      causes. Survival was similar in recipients of related (55%) and unrelated grafts 
      (48%). Risk factors identified in univariate analysis were brought into a 
      multivariable analysis. However, an unrelated donor was not identified as a risk 
      factor for any of the five end-points analysed. A donor positive for three to 
      four herpes viruses increased the risk of acute GVHD, TRM and death. A female to 
      male transplant increased the risk of TRM, particularly if combined with a 
      mismatch. Early stage of disease as well as human leukocyte antigen 
      (HLA)-matching independently predicted survival. The risk of relapse increased 
      after 1992. Chronic GVHD independently decreased the risk of relapse (relative 
      risk RR, 0.39) and death (RR 0.42). We conclude that in children with leukemia 
      other specific donor characteristics such as HLA-matching, gender, parity, and 
      exposure to herpes viruses were more important for outcome than relationship.
CI  - Copyright 2004 Blackwell Munksgaard
FAU - Gustafsson Jernberg, Asa
AU  - Gustafsson Jernberg A
AD  - Department of Pediatrics, Karolinska Institutet, Huddinge University Hospital, 
      Stockholm, Sweden. asa.gustafsson@klinvet.ki.se
FAU - Remberger, Mats
AU  - Remberger M
FAU - Ringden, Olle
AU  - Ringden O
FAU - Winiarski, Jacek
AU  - Winiarski J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/etiology/mortality
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia/*therapy
MH  - Male
MH  - Multivariate Analysis
MH  - Postoperative Care
MH  - Proportional Hazards Models
MH  - Recurrence
MH  - Risk Factors
MH  - Sex Factors
MH  - *Stem Cell Transplantation/adverse effects
MH  - Survival Analysis
MH  - Survival Rate
EDAT- 2004/09/16 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/09/16 05:00
PHST- 2004/09/16 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/09/16 05:00 [entrez]
AID - PTR175 [pii]
AID - 10.1111/j.1399-3046.2004.00175.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2004 Oct;8(5):464-74. doi: 10.1111/j.1399-3046.2004.00175.x.