PMID- 15367509
OWN - NLM
STAT- MEDLINE
DCOM- 20041004
LR  - 20181113
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 90
IP  - 10
DP  - 2004 Oct
TI  - Exercise capacity and cardiac function assessed by tissue Doppler imaging in 
      chronic heart failure.
PG  - 1144-50
AB  - OBJECTIVE: To examine the relation between longitudinal left ventricular function 
      assessed by tissue Doppler imaging (TDi) and exercise capacity in heart failure. 
      SUBJECTS: 153 patients with chronic heart failure from left ventricular systolic 
      dysfunction (ejection fraction < 45%) and 87 age and sex matched controls. 
      METHODS: Echocardiography was used to measure conventional indices of left 
      ventricular systolic function. TDi was used to assess left and right ventricular 
      longitudinal function by measuring mitral and lateral tricuspid annular 
      velocities during the cardiac cycle. Velocities measured at each point were the 
      systolic peak (S(m)) and the diastolic troughs (E(m) and A(m)), corresponding to 
      passive and active (atrial) left ventricular filling. Each patient also underwent 
      treadmill exercise testing with metabolic gas exchange measurements. RESULTS: 
      Left and right ventricular TDi velocities were greater in controls than in 
      patients. Left ventricular ejection fraction (LVEF) correlated with S(m) (r = 
      0.30, p = 0.0005), but not with E(m), A(m), or the E(m)/A(m) ratio. There were no 
      significant differences between New York Heart Association (NYHA) functional 
      class for any of the TDi variables. Right ventricular indices were not related to 
      exercise capacity. Systolic myocardial motion measured by TDi correlated more 
      closely with peak oxygen consumption (pVO2) (r = 0.35, p < 0.0001) than LVEF (r = 
      0.21, p < 0.02). The E(m)/A(m) ratio was not correlated with pVO2. In multiple 
      regression, S(m) was the only left ventricular TDi variable to predict exercise 
      capacity independently (p < 0.05). CONCLUSIONS: Exercise capacity and symptoms 
      are poorly related to conventional measures of cardiac function and more closely 
      correlated with indices of longitudinal left ventricular function as assessed by 
      TDi.
FAU - Witte, K K A
AU  - Witte KK
AD  - Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 
      5JQ, UK. klauswitte@hotmail.com
FAU - Nikitin, N P
AU  - Nikitin NP
FAU - De Silva, R
AU  - De Silva R
FAU - Cleland, J G F
AU  - Cleland JG
FAU - Clark, A L
AU  - Clark AL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Echocardiography, Doppler
MH  - Echocardiography, Doppler, Color
MH  - *Exercise Tolerance
MH  - Female
MH  - Heart Failure/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Pulmonary Gas Exchange
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnostic imaging
PMC - PMC1768502
EDAT- 2004/09/16 05:00
MHDA- 2004/10/05 09:00
PMCR- 2007/10/01
CRDT- 2004/09/16 05:00
PHST- 2004/09/16 05:00 [pubmed]
PHST- 2004/10/05 09:00 [medline]
PHST- 2004/09/16 05:00 [entrez]
PHST- 2007/10/01 00:00 [pmc-release]
AID - 90/10/1144 [pii]
AID - 0901144 [pii]
AID - 10.1136/hrt.2003.025684 [doi]
PST - ppublish
SO  - Heart. 2004 Oct;90(10):1144-50. doi: 10.1136/hrt.2003.025684.