PMID- 15367878
OWN - NLM
STAT- MEDLINE
DCOM- 20041208
LR  - 20190717
IS  - 0002-9629 (Print)
IS  - 0002-9629 (Linking)
VI  - 328
IP  - 3
DP  - 2004 Sep
TI  - Antineutrophil cytoplasmic autoantibody-associated rapidly progressive 
      glomerulonephritis in a patient with primary biliary cirrhosis.
PG  - 176-9
AB  - A 72-year-old woman with primary biliary cirrhosis (PBC) and antineutrophil 
      cytoplasmic autoantibody (ANCA)-associated rapidly progressive glomerulonephritis 
      is described. She had a 6-year history of PBC diagnosed histologically, with a 
      positive test finding for antimitochondrial antibodies and elevated biliary 
      enzyme activity. The myeloperoxidase-ANCA test result was negative. The patient 
      was treated with ursodeoxycholic acid (600 mg/day) and had been stable for 6 
      years. She was admitted to our hospital because of general fatigue, exertional 
      dyspnea, and peripheral edema. Her serum level of creatinine was increased (4.4 
      mg/dL), and her hemoglobin concentration was reduced (8.0 g/dL). The patient was 
      diagnosed as having rapidly progressive glomerulonephritis. Test results for 
      serum antinuclear antibody and myeloperoxidase-ANCA were positive. The diagnosis 
      by renal biopsy was necrotizing crescentic glomerulonephritis. Prednisolone 
      followed by methylprednisolone pulse therapy and cyclophosphamide were 
      administered. The patient underwent plasma exchange twice weekly for 4 weeks. 
      After 4 weeks, her serum creatinine level fell to 1.8 mg/dL, and she recovered 
      renal function without hemodialysis. After 24 weeks, her renal function (serum 
      creatinine level, 1.6 mg/dL) was stable.
FAU - Nakamura, Tsukasa
AU  - Nakamura T
AD  - Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan.
FAU - Kawagoe, Yasuhiro
AU  - Kawagoe Y
FAU - Ueda, Yoshihiko
AU  - Ueda Y
FAU - Koide, Hikaru
AU  - Koide H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunosuppressive Agents)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - VB0R961HZT (Prednisone)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Aged
MH  - Antibodies, Antineutrophil Cytoplasmic/*blood
MH  - Biopsy
MH  - Cyclophosphamide/therapeutic use
MH  - Female
MH  - Glomerulonephritis/etiology/*immunology/pathology/therapy
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Liver Cirrhosis, Biliary/complications/*immunology/therapy
MH  - Methylprednisolone/therapeutic use
MH  - Peroxidase/blood
MH  - Plasma Exchange
MH  - Prednisone/therapeutic use
MH  - Treatment Outcome
EDAT- 2004/09/16 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/16 05:00
PHST- 2004/09/16 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/16 05:00 [entrez]
AID - S0002-9629(15)33992-6 [pii]
AID - 10.1097/00000441-200409000-00009 [doi]
PST - ppublish
SO  - Am J Med Sci. 2004 Sep;328(3):176-9. doi: 10.1097/00000441-200409000-00009.