PMID- 1536953
OWN - NLM
STAT- MEDLINE
DCOM- 19920330
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 79
IP  - 5
DP  - 1992 Mar 1
TI  - Extensive cross-homology between the long and the short arm of chromosome 16 may 
      explain leukemic inversions and translocations.
PG  - 1299-304
AB  - Specific rearrangements of chromosome 16 are well known in acute nonlymphocytic 
      leukemia with abnormal eosinophils. While mapping cosmids relative to breakpoints 
      in chromosome 16 in leukemic cells with fluorescence in situ hybridization 
      (FISH), we have identified three areas of extensive cross-homology between 16p 
      and 16q. Three cosmids among 99 tested showed two large signals on the short arm 
      and one signal on the long arm of chromosome 16. A fourth cosmid showed mainly 
      two signals on the short arm. With the 16p-specific cosmid we can demonstrate 
      that the breakpoints of a pericentric inversion and a reciprocal (16;16) 
      translocation, both of which are characteristic for acute leukemia, map to the 
      most distal of two blocks on the short arm. We suggest that there may be at least 
      two distinct repetitive elements specific for chromosome 16 interdigitated on 
      16p. The presence of a similar repeat in the short, as well as the long arm of 
      the chromosome, may play a role in the origin of chromosome 16 rearrangements in 
      acute leukemia.
FAU - Dauwerse, J G
AU  - Dauwerse JG
AD  - Department of Human Genetics, State University Leiden, Sylvius Laboratories, The 
      Netherlands.
FAU - Jumelet, E A
AU  - Jumelet EA
FAU - Wessels, J W
AU  - Wessels JW
FAU - Saris, J J
AU  - Saris JJ
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Beverstock, G C
AU  - Beverstock GC
FAU - van Ommen, G J
AU  - van Ommen GJ
FAU - Breuning, M H
AU  - Breuning MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Acute Disease
MH  - *Chromosome Inversion
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 16/*ultrastructure
MH  - Cosmids
MH  - Humans
MH  - Leukemia/*genetics
MH  - Nucleic Acid Hybridization
MH  - Repetitive Sequences, Nucleic Acid
MH  - Sequence Homology, Nucleic Acid
MH  - *Translocation, Genetic
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - S0006-4971(20)73754-7 [pii]
PST - ppublish
SO  - Blood. 1992 Mar 1;79(5):1299-304.