PMID- 15370207
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 45
IP  - 8
DP  - 2004 Aug
TI  - Molecular-cytogenetic characterization of non-Hodgkin's lymphoma with double and 
      cryptic translocations of the immunoglobulin heavy chain gene.
PG  - 1559-67
AB  - The present study aimed to characterize the clinical and molecular-cytogenetic 
      features of non-Hodgkin's lymphoma (NHL) with double translocation of the 
      immunoglobulin heavy chain (IGH) gene. G-banding analysis, fluorescence in situ 
      hybridization (FISH) with the IGH (Cgamma and VH) and oncogene (c-MYC, BCL1, 
      BCL2, and BCL6) probes, and long-distance polymerase chain reaction (LD-PCR) were 
      performed on 6 patients with B-cell lymphoma, one with angioimmunoblastic T-cell 
      lymphoma, and one with acute lymphoblastic leukemia (ALL) with B-cell phenotype. 
      G-banding analysis detected two different 14q32 translocations, t(14,18) and add 
      (14)(q32) in a patient with ALL. Two distinct partners of double IGH 
      translocation identified by FISH were as follows: c-MYC + BCL2 in 3 patients, 
      c-MYC + BCL1 in 2, c-MYC + BCL6 in one, BCL2 + 9q22 in one, and 1q21 + 6q27 in 
      one. Colocalization of BCL1 and c-MYC probes was demonstrated in a patient with 
      mantle cell lymphoma. LD-PCR detected c-MYC/Cmu, c-MYC/Calpha and BCL6/Cmu, and 
      c-MYC/Calpha fusion in each one patient. Seven of 8 patients showed high serum 
      LDH. Central nervous system and leukemic involvement was observed in 5 and 6 
      patients, respectively. Median survival time of patients with c-MYC/IGH 
      translocation was 9 months. The results defined a clinical subset of B-cell 
      lymphoma/leukemia showing extremely poor prognosis. C-MYC/IGH translocation is 
      possibly an evolutionary alteration following the primary IGH translocation with 
      BCL1, BCL2, or BCL6. Furthermore, FISH identified one novel (9q22) and one 
      cryptic chromosomal breakpoints (6q27) involved in IGH translocation.
FAU - Kanda-Akano, Yumiko
AU  - Kanda-Akano Y
AD  - Division of Hematology and Oncology, Department of Internal Medicine, Kyoto 
      Prefectural University of Medicine, Kyoto, Japan.
FAU - Nomura, Kenichi
AU  - Nomura K
FAU - Fujita, Yasuko
AU  - Fujita Y
FAU - Horiike, Shigeo
AU  - Horiike S
FAU - Nishida, Kazuhiro
AU  - Nishida K
FAU - Nagai, Masami
AU  - Nagai M
FAU - Miura, Ikuo
AU  - Miura I
FAU - Nakamura, Shigeo
AU  - Nakamura S
FAU - Seto, Masao
AU  - Seto M
FAU - Iida, Shinsuke
AU  - Iida S
FAU - Ueda, Ryuzo
AU  - Ueda R
FAU - Taniwaki, Masafumi
AU  - Taniwaki M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Transcription Factors)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Banding
MH  - Cyclin D1/genetics
MH  - Cytogenetic Analysis
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Genes, Immunoglobulin/*genetics
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/*genetics
MH  - Lymphoma, Follicular/genetics
MH  - Lymphoma, Mantle-Cell/genetics
MH  - Lymphoma, T-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-bcl-2/genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Proto-Oncogene Proteins c-myc/genetics
MH  - Transcription Factors/genetics
MH  - *Translocation, Genetic
EDAT- 2004/09/17 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/09/17 05:00
PHST- 2004/09/17 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/09/17 05:00 [entrez]
AID - YLJW3FXC53N56P00 [pii]
AID - 10.1080/10428190310001625674 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2004 Aug;45(8):1559-67. doi: 10.1080/10428190310001625674.