PMID- 15370888
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20131121
IS  - 1521-6543 (Print)
IS  - 1521-6543 (Linking)
VI  - 56
IP  - 5
DP  - 2004 May
TI  - Methamphetamine and MDMA (ecstasy) neurotoxicity: 'of mice and men'.
PG  - 249-55
AB  - Methamphetamine (METH) and 3,4-meythylenedioxymethamphetamine (MDMA; 'ecstasy') 
      are currently major drugs of abuse. One of the major concerns of amphetamines 
      abuse is their potential neurotoxic effect on dopaminergic and serotonergic 
      neurons. Although data from human studies are somewhat limited, compelling 
      evidence suggests that these drugs cause neurotoxicity in rodents and primates. 
      Recent studies in transgenic and knockout mice identified the role of dopamine 
      transporters, nitric oxide, apoptotic proteins, and inflammatory cytokines in 
      amphetamines neurotoxicity. Further research into the mechanisms underlying the 
      dopaminergic and serotonergic neurotoxicity and the behavioral corollaries of 
      these neuronal insults could facilitate our understanding of the consequences of 
      human abuse of METH and MDMA on cognition, drug-seeking behavior, extinction and 
      relapse.
FAU - Itzhak, Yossef
AU  - Itzhak Y
AD  - Department of Psychiatry and Behavioral Science and the Neuroscience Program, 
      University of Miami School of Medicine, Miami, Florida 33136, USA. 
      yitzhak@med.miami.edu
FAU - Achat-Mendes, Cindy
AU  - Achat-Mendes C
LA  - eng
GR  - DA12867/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - IUBMB Life
JT  - IUBMB life
JID - 100888706
RN  - 0 (Psychotropic Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain/cytology/*drug effects
MH  - Humans
MH  - Methamphetamine/analogs & derivatives/*toxicity
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analogs & derivatives/*toxicity
MH  - Neurons/*drug effects
MH  - Psychotropic Drugs/*toxicity
RF  - 40
EDAT- 2004/09/17 05:00
MHDA- 2005/02/23 09:00
CRDT- 2004/09/17 05:00
PHST- 2004/09/17 05:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/09/17 05:00 [entrez]
AID - 6TBL52C5EMM4MKT4 [pii]
AID - 10.1080/15216540410001727699 [doi]
PST - ppublish
SO  - IUBMB Life. 2004 May;56(5):249-55. doi: 10.1080/15216540410001727699.