PMID- 15371688
OWN - NLM
STAT- MEDLINE
DCOM- 20041209
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 78
IP  - 5
DP  - 2004 Sep 15
TI  - Human leukocyte antigen type as a risk factor for nonmelanomatous skin cancer in 
      patients after renal transplantation.
PG  - 775-8
AB  - Renal-transplant recipients are at an increased risk for developing 
      nonmelanomatous skin cancer (NMSC). Recipient human leukocyte antigen (HLA) type 
      has been suggested as a possible risk factor. We studied the association between 
      HLA type and posttransplant NMSC in 2,433 renal-transplant recipients in a 
      Northern climate, for whom HLA type and clinical follow-up were available. One 
      hundred six (4.3%) patients developed NMSC between 1984 and 1997. Of previously 
      reported HLA-associated risk factors, only HLA A11 showed an increased incidence 
      of posttransplant skin cancer, at 8% (P=0.0137, odds ratio 2.03 with 95% 
      confidence interval 1.11-3.53) in 1998. This effect persisted at follow-up, in a 
      limited reanalysis in 2004. HLA A11 may be a useful marker, in some populations, 
      for identifying at the time of transplantation those patients that are at an 
      increased risk for NMSC and who may therefore be good candidates for preventative 
      clinical trials.
FAU - Bock, Adam
AU  - Bock A
AD  - Department of Medicine Residency Program and Clinical Research Center, University 
      of Minnesota, Minneapolis, MN, USA.
FAU - Bliss, Robin L
AU  - Bliss RL
FAU - Matas, Arthur
AU  - Matas A
FAU - Little, Jane A
AU  - Little JA
LA  - eng
GR  - DK 13083 5/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - HLA Antigens/*classification
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Skin Neoplasms/*epidemiology/immunology
EDAT- 2004/09/17 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/09/17 05:00
PHST- 2004/09/17 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/09/17 05:00 [entrez]
AID - 00007890-200409150-00028 [pii]
AID - 10.1097/01.tp.0000131666.17216.11 [doi]
PST - ppublish
SO  - Transplantation. 2004 Sep 15;78(5):775-8. doi: 10.1097/01.tp.0000131666.17216.11.