PMID- 15371956
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20190823
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 28
IP  - 10
DP  - 2004 Oct
TI  - Prostatic acid phosphatase is a possible tumor marker for intravascular large 
      B-cell lymphoma.
PG  - 1384-8
AB  - Intravascular large B-cell lymphoma (LBCL) is a rare and aggressive subtype of 
      diffuse LBCL characterized by disseminated intravascular proliferation of 
      neoplastic lymphocytes. Obstruction of blood flow by tumor cells in a variety of 
      organs can cause an array of clinical changes, including alteration of the neural 
      and spinal system and the respiratory system, as well as skin lesions. It is 
      usually very difficult to diagnose intravascular LBCL in a patient simply from 
      clinical symptoms or laboratory examinations. We here document our findings that 
      serum prostatic acid phosphatase levels in both males and a female (2.2-24.0 
      microg/L) reflect the presence of intravascular LBCL, changing synchronously in 
      response to chemotherapy. To determine whether prostatic acid phosphatase (PAP) 
      might be a useful tumor marker for early diagnosis, we reviewed five 
      intravascular LBCLs. Immunohistochemically, tumor cells in all cases were 
      positive for anti-PAP antibody. The results were further confirmed in one case by 
      Western-blot analysis and in another by the detection of amplified messenger RNA 
      for PAP in microdissected tumor cells, respectively. PAP has not been detected in 
      17 lymphomas (diffuse LBCL, 8 cases; follicular lymphoma, 3 cases; T-cell 
      lymphoma, 3 cases; Hodgkin lymphoma, 3 cases) by Western blot analyses. We 
      conclude that serum PAP is a useful tumor marker for intravascular LBCL and that 
      it deserves further investigation in this context.
FAU - Seki, Kunihiko
AU  - Seki K
AD  - Department of Pathology, , University of Tokyo, Toranomon Hospital, 2-2-2 
      Toranomon, Minato-ku, Tokyo 105-8470, Japan. seki1960@toranomon.gr.jp
FAU - Miyakoshi, Shigesaburoh
AU  - Miyakoshi S
FAU - Lee, Gang-Hong
AU  - Lee GH
FAU - Matsushita, Hiroshi
AU  - Matsushita H
FAU - Mutoh, Yoshitomo
AU  - Mutoh Y
FAU - Nakase, Kohji
AU  - Nakase K
FAU - Ida, Masayoshi
AU  - Ida M
FAU - Taniguchi, Hirokazu
AU  - Taniguchi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Messenger)
RN  - EC 3.1.3.2 (Acid Phosphatase)
RN  - EC 3.1.3.2 (prostatic acid phosphatase)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Acid Phosphatase
MH  - Biomarkers, Tumor/*analysis/blood
MH  - Blotting, Western
MH  - Dissection
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laser Therapy
MH  - Leukocyte Common Antigens/analysis
MH  - Lymphoma, B-Cell/*enzymology/surgery
MH  - Lymphoma, Large B-Cell, Diffuse/*enzymology/surgery
MH  - Male
MH  - Middle Aged
MH  - Protein Tyrosine Phosphatases/*analysis/blood/genetics
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Vascular Neoplasms/*enzymology/surgery
EDAT- 2004/09/17 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/09/17 05:00
PHST- 2004/09/17 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/09/17 05:00 [entrez]
AID - 00000478-200410000-00016 [pii]
AID - 10.1097/01.pas.0000132743.89349.35 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2004 Oct;28(10):1384-8. doi: 
      10.1097/01.pas.0000132743.89349.35.