PMID- 15373561
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050315
LR  - 20161021
IS  - 0894-203X (Print)
IS  - 0894-203X (Linking)
VI  - 18
IP  - 2
DP  - 2002
TI  - Neonatal alloimmune thrombocytopenia due to HPA-3a antibodies: a case report.
PG  - 33-6
AB  - A healthy infant was born at term by elective cesarean section to a 32-year-old 
      para 4, gravida 4, mother. Within 24 hours, the infant was noted to have fairly 
      extensive bruising on the back and shoulders. A full blood count evaluation was 
      remarkable for severe thrombocytopenia (platelet count of 29 x 10(9)/L). Other 
      hematologic parameters were normal. Human leukocyte antigen (HLA) class-1 
      antibodies but not platelet-specific antibodies were detectable in the maternal 
      serum using a commercial antigen-capture ELISA (GTI-PakPlus kit). Anti-HPA-3a 
      antibodies, while weakly reactive in the monoclonal antibody immobilization of 
      platelet antigens (MAIPA) assay in the immediate postpartum serum, were readily 
      detectable using this assay in a sample taken 4 weeks later. Genotyping for human 
      platelet antigens (HPA) 1-5 by the polymerase chain reaction technique with 
      sequence-specific primers (PCR-SSP) revealed the infant's platelet genotype to be 
      HPA-1a/1a, 3a/3b, while that of the mother was HPA-1a/1a, 3b/ 3b, consistent with 
      a diagnosis of anti-HPA-3a neonatal alloimmune thrombocytopenia (NAIT). This case 
      illustrates the increased sensitivity of the MAIPA technique for the detection of 
      platelet-specific antibodies. We believe this to be the first serologically 
      confirmed case of NAIT due to anti-HPA-3a to be reported in the republic of 
      Ireland.
FAU - Davoren, A
AU  - Davoren A
AD  - Blood Research Institute, Blood Center of SE Wisconsin, 638 N. 18th St., 
      Milwaukee, WI 53201, USA.
FAU - Smith, G
AU  - Smith G
FAU - Lucas, G
AU  - Lucas G
FAU - Rodgers, S
AU  - Rodgers S
FAU - O'Donoghue, P
AU  - O'Donoghue P
FAU - Crowley, J
AU  - Crowley J
FAU - Barnes, C A
AU  - Barnes CA
FAU - McKiernan, J
AU  - McKiernan J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Immunohematology
JT  - Immunohematology
JID - 8806387
EDAT- 2004/09/18 05:00
MHDA- 2004/09/18 05:01
CRDT- 2004/09/18 05:00
PHST- 2004/09/18 05:00 [pubmed]
PHST- 2004/09/18 05:01 [medline]
PHST- 2004/09/18 05:00 [entrez]
PST - ppublish
SO  - Immunohematology. 2002;18(2):33-6.