PMID- 15373782
OWN - NLM
STAT- MEDLINE
DCOM- 20041108
LR  - 20071114
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 123
IP  - 4
DP  - 2004 Oct
TI  - Epidermal growth factor gene (EGF) polymorphism and risk of melanocytic 
      neoplasia.
PG  - 760-2
AB  - A common single nucleotide polymorphism (SNP) in the 5' untranslated region 
      (5'UTR) of the epidermal growth factor (EGF) gene modulates the level of 
      transcription of this gene and hence is associated with serum levels of EGF. This 
      variant may be associated with melanoma risk, but conflicting findings have been 
      reported. An Australian melanoma case-control sample was typed for the EGF+61A>G 
      transversion (rs4444903). The sample comprised 753 melanoma cases from 738 
      families stratified by family history of melanoma and 2387 controls from 645 
      unselected twin families. Ancestry of the cases and controls was recorded, and 
      the twins had undergone skin examination to assess total body nevus count, degree 
      of freckling and pigmentation phenotype. SNP genotyping was carried out via 
      primer extension followed by matrix-assisted laser desorption time of flight 
      (MALDI-TOF) mass spectroscopy. The EGF+61 SNP was not found to be significantly 
      associated with melanoma status or with development of nevi or freckles. Among 
      melanoma cases, however, G homozygotes had thicker tumors (p=0.05), in keeping 
      with two previous studies. The EGF polymorphism does not appear to predispose to 
      melanoma or nevus development, but its significant association with tumor 
      thickness implies that it may be a useful marker of prognosis.
FAU - James, Michael R
AU  - James MR
AD  - Queensland Institute of Medical Research, Brisbane, Australia.
FAU - Hayward, Nicholas K
AU  - Hayward NK
FAU - Dumenil, Troy
AU  - Dumenil T
FAU - Montgomery, Grant W
AU  - Montgomery GW
FAU - Martin, Nicholas G
AU  - Martin NG
FAU - Duffy, David L
AU  - Duffy DL
LA  - eng
GR  - CA88363/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
CIN - J Invest Dermatol. 2004 Oct;123(4):xx-xxi. PMID: 15373802
MH  - Case-Control Studies
MH  - Epidermal Growth Factor/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - Humans
MH  - Melanoma/epidemiology/*genetics/pathology
MH  - Melanosis/epidemiology/genetics
MH  - Nevus/epidemiology/genetics
MH  - *Polymorphism, Genetic
MH  - Prognosis
MH  - Risk Factors
MH  - Skin Neoplasms/epidemiology/*genetics/pathology
EDAT- 2004/09/18 05:00
MHDA- 2004/11/09 09:00
CRDT- 2004/09/18 05:00
PHST- 2004/09/18 05:00 [pubmed]
PHST- 2004/11/09 09:00 [medline]
PHST- 2004/09/18 05:00 [entrez]
AID - S0022-202X(15)30978-7 [pii]
AID - 10.1111/j.0022-202X.2004.23305.x [doi]
PST - ppublish
SO  - J Invest Dermatol. 2004 Oct;123(4):760-2. doi: 10.1111/j.0022-202X.2004.23305.x.