PMID- 15374299
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050310
LR  - 20191026
IS  - 0167-4943 (Print)
IS  - 0167-4943 (Linking)
VI  - 18
IP  - 3
DP  - 1994 May-Jun
TI  - Effects of age and dietary restriction on liver glutathione transferase 
      activities in Lobund-Wistar rats.
PG  - 191-205
AB  - Glutathione-S-transferases (GST) are a group of enzymes which detoxify 
      electrophilic xenobiotics (including drugs, carcinogens and their metabolites), 
      and thus may be involved in the age-related pathologic process. Effects of a 30% 
      dietary restriction on liver GST activities toward seven substrates were studied 
      in male Lobund-Wistar (L-W) rats at 6, 12, 18, 24 and 30 months of age. The 
      enzyme activities in the ad libitum (AL) group toward 1-chloro-2,4-dinitrobenzene 
      (CDNB), bromosulfophthalein (BSP), 4-nitropyridine-N-oxide (NPNO), p-nitrobenzyl 
      chloride (NBC), trans-4-phenyl-3-buten-2-one (PBO) and styrene oxide (STOX) did 
      not change with age, while those toward 1,2-dicholoro-4-nitrobenzene (DCNB) 
      decreased after middle age. The enzyme activities in the dietary restricted (DR) 
      group toward CDNB and STOX did not change with age, while those toward DCNB, BSP, 
      NPNO, NBC and PBO decreased after middle age. The DR group had significantly 
      higher GST activities than the AL group, especially at 18 months, when BSP, NPNO, 
      NBC and PBO were used as the substrates. Dietary restriction did not affect GST 
      activities toward all seven substrates at old age. These results are 
      substrate-specific, indicating that isozyme-specific changes in GST activities 
      occur with dietary restriction and aging. The results suggest that dietary 
      restriction enhances liver detoxification capability associated with GSH 
      conjugation in middle age, which may contribute to the delaying of the 
      age-related pathologic process until a later point in life in this animal model.
FAU - Chen, L H
AU  - Chen LH
AD  - Department of Nutrition and Food Science, 219 Funkhouser Building, University of 
      Kentucky, Lexington, KY 40506-0054, USA.
FAU - Hu, N
AU  - Hu N
FAU - Snyder, D L
AU  - Snyder DL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1993/12/20 00:00 [received]
PHST- 1994/03/08 00:00 [revised]
PHST- 1994/03/10 00:00 [accepted]
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0167494394900132 [pii]
AID - 10.1016/0167-4943(94)90013-2 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 1994 May-Jun;18(3):191-205. doi: 
      10.1016/0167-4943(94)90013-2.