PMID- 15374751
OWN - NLM
STAT- MEDLINE
DCOM- 20050124
LR  - 20221207
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1023
IP  - 2
DP  - 2004 Oct 15
TI  - Evidence for serotonin receptor subtypes involvement in agmatine antidepressant 
      like-effect in the mouse forced swimming test.
PG  - 253-63
AB  - This study investigated the involvement of 5-HT(1) and 5-HT(2) receptors in the 
      antidepressant-like effect of agmatine in the mouse forced swimming test (FST). 
      Pretreatment with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, 
      intraperitoneally (i.p.), an inhibitor of serotonin synthesis, for 4 consecutive 
      days), methysergide (5 mg/kg, i.p., a serotonin (5-HT) antagonist), pindolol (32 
      mg/kg, i.p., a 5-HT(1A/1B) receptor/beta-adrenoceptor antagonist), 
      N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridynyl)cyclohexanecarboxamide 
      (WAY 100635; 0.3 mg/kg, subcutaneously (s.c.), a selective 5-HT(1A) receptor 
      antagonist), 1-(2-methoxyphenyl)-4[-(2-phthalimido)butyl]piperazine) (NAN-190; 
      0.5 mg/kg, i.p., a 5-HT(1A) receptor antagonist), 
      1-(2-(1-pyrrolyl)-phenoxy)-3-isopropylamino-2-propanol (isamoltane; 2.5 mg/kg, 
      i.p., a 5-HT(1B) receptor antagonist), cyproheptadine (3 mg/kg, i.p., a 5-HT(2) 
      antagonist) or ketanserin (5 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist), but 
      not with propranolol (2 mg/kg, i.p., a beta-adrenoceptor antagonist), prevented 
      the effect of agmatine (10 mg/kg, i.p.) in the FST. A subeffective dose of 
      agmatine (0.001 mg/kg, i.p.) produced a synergistic antidepressant-like effect 
      with pindolol (32 mg/kg), NAN-190 (0.5 mg/kg, i.p.), WAY 100635 (0.03 mg/kg, 
      s.c.), (+)-8-hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT; 0.01 mg/kg, 
      i.p., a 5-HT(1A) receptor agonist), 
      R(-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI; 1 mg/kg, i.p., a 
      preferential 5-HT(2A) receptor agonist), or fluoxetine (10 mg/kg, i.p., a 
      selective serotonin reuptake inhibitor, SSRI) but not with isamoltane (2.5 mg/kg, 
      i.p.), ritanserin (4 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist) or 
      ketanserin (5 mg/kg, i.p.). Taken together, the results firstly demonstrate that 
      agmatine antidepressant-like effects in the FST seem to be mediated, at least in 
      part, by an interaction with 5-HT(1A/1B) and 5-HT(2) receptors.
FAU - Dias Elpo Zomkowski, Andrea
AU  - Dias Elpo Zomkowski A
AD  - Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal 
      de Santa Catarina, Campus Universitario, Trindade, Florianopolis 88040-900, SC, 
      Brazil.
FAU - Oscar Rosa, Angelo
AU  - Oscar Rosa A
FAU - Lin, Jaime
AU  - Lin J
FAU - Santos, Adair R S
AU  - Santos AR
FAU - Calixto, Joao Batista
AU  - Calixto JB
FAU - Lucia Severo Rodrigues, Ana
AU  - Lucia Severo Rodrigues A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antidepressive Agents)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 23434-96-0 (4-chlorophenylalanine methyl ester)
RN  - 70J407ZL5Q (Agmatine)
RN  - R5J7E3L9SP (Fenclonine)
RN  - XZA9HY6Z98 (Methysergide)
SB  - IM
MH  - Agmatine/*therapeutic use
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Behavior, Animal
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Female
MH  - Fenclonine/*analogs & derivatives/pharmacology
MH  - Fluoxetine/pharmacology
MH  - Immobility Response, Tonic/drug effects
MH  - Male
MH  - Methysergide/pharmacology
MH  - Mice
MH  - Receptors, Serotonin/classification/*physiology
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - *Swimming
EDAT- 2004/09/18 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/09/18 05:00
PHST- 2004/07/13 00:00 [accepted]
PHST- 2004/09/18 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/09/18 05:00 [entrez]
AID - S0006-8993(04)01177-1 [pii]
AID - 10.1016/j.brainres.2004.07.041 [doi]
PST - ppublish
SO  - Brain Res. 2004 Oct 15;1023(2):253-63. doi: 10.1016/j.brainres.2004.07.041.