PMID- 15377799
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20220409
IS  - 0022-3859 (Print)
IS  - 0022-3859 (Linking)
VI  - 50
IP  - 3
DP  - 2004 Jul-Sep
TI  - Clinical and familial correlates of tardive dyskinesia in India and Israel.
PG  - 167-72; discussion 172
AB  - BACKGROUND: Antipsychotic drugs are widely used for the treatment of psychosis, 
      especially schizophrenia. Their long-term use can result at times in serious 
      side-effects such as Tardive Dyskinesia (TD). Since over 80% of schizophrenia 
      sufferers (lifetime prevalence 1%) receive long-term antipsychotic drug 
      treatment, the extent of the problem is potentially large. Increasing age is the 
      most consistently demonstrated risk factor for TD. AIMS: To assess effect of 
      different clinical factors and demographic variables in India and Israel and sib 
      pair concordance of Tardive Dyskinesia (TD) in India. SETTINGS AND DESIGN: The 
      study was conducted simultaneously among Indian and Israeli subjects: 
      ascertainment was family-based in India and hospital-based in Israel. METHODS AND 
      MATERIAL: In India the instruments used were: Diagnostic Interview for Genetic 
      Studies (DIGS), Positive and Negative Syndrome Scale (PANSS), Abnormal 
      Involuntary Movement Scale (AIMS), and Simpson Angus Scale (SAS). The last three 
      instruments were also used in Israel. STATISTICAL ANALYSIS: Regression analysis 
      and Pearson's correlation. RESULTS AND CONCLUSIONS: TD symptoms were present in 
      40.4% of 151 Israeli subjects and 28.7% of 334 Indian subjects. While age at 
      onset and total scores on PANSS were significant predictors of TD in both the 
      samples, lower scores on the Global Assessment of Functioning Scale (GAF), 
      diagnostic sub-group and male gender were significant predictors among Indians. 
      There was no concordance of TD symptoms among 33 affected sib-pairs from India.
FAU - Bhatia, T
AU  - Bhatia T
AD  - Indo US Project on Schizophrenia Genetics, Molecular Genetics of Tardive 
      Dyskinesia.
FAU - Sabeeha, M R
AU  - Sabeeha MR
FAU - Shriharsh, V
AU  - Shriharsh V
FAU - Garg, K
AU  - Garg K
FAU - Segman, R H
AU  - Segman RH
FAU - Uriel, H L
AU  - Uriel HL
FAU - Strous, R
AU  - Strous R
FAU - Nimgaonkar, V L
AU  - Nimgaonkar VL
FAU - Bernard, L
AU  - Bernard L
FAU - Deshpande, S N
AU  - Deshpande SN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*adverse effects
MH  - Dyskinesia, Drug-Induced/*epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Israel/epidemiology
MH  - Male
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
EDAT- 2004/09/21 05:00
MHDA- 2005/04/20 09:00
CRDT- 2004/09/21 05:00
PHST- 2004/09/21 05:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2004/09/21 05:00 [entrez]
PST - ppublish
SO  - J Postgrad Med. 2004 Jul-Sep;50(3):167-72; discussion 172.