PMID- 15379988
OWN - NLM
STAT- MEDLINE
DCOM- 20041112
LR  - 20181113
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 113
IP  - 2
DP  - 2004 Oct
TI  - Resistance to re-challenge in the Brown Norway rat model of vasculitis is not 
      always complete and may reveal separate effector and regulatory populations.
PG  - 269-76
AB  - Administration of mercuric chloride to Brown Norway rats results in T helper type 
      2 (Th2)- dominated autoimmunity characterized by high immunoglobulin E (IgE) 
      concentrations, the production of multiple IgG autoantibodies, including those to 
      glomerular basement membrane (GBM), arthritis and caecal vasculitis. After 14 
      days animals immunoregulate and auto-immunity resolves even if mercuric chloride 
      injections are continued. In a third phase, if animals are re-challenged with 
      mercuric chloride 6 weeks later, they show only attenuated autoimmunity with 
      lower anti-GBM antibody concentrations and arthritis scores. Resistance to the 
      induction of anti-GBM antibodies can also be achieved following an initial 
      challenge with low-dose (one-tenth standard dose) mercuric chloride. We have now 
      studied this resistant phase in more detail. We have shown, first, that following 
      an initial full-dose mercuric chloride challenge, resistance also affects 
      susceptibility to caecal vasculitis. Second, following an initial full-dose 
      mercuric chloride challenge, the IgE response upon re-challenge is initially 
      accelerated but subsequently enters a resistant phase and third, following an 
      initial challenge with low-dose mercuric chloride, resistance is also seen to the 
      induction of caecal vasculitis but is not seen in IgE serology (where results 
      suggest competing effector and regulatory cell populations). Studying such 
      regulatory phases in animal models of autoimmunity may be of benefit in the 
      future in designing new therapies for human vasculitis.
FAU - Vinen, C S
AU  - Vinen CS
AD  - Department of Renal Medicine, St George's Hospital Medical School, Cranmer 
      Terrace, London, UK.
FAU - Turner, D R
AU  - Turner DR
FAU - Oliveira, D B G
AU  - Oliveira DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 53GH7MZT1R (Mercuric Chloride)
SB  - IM
MH  - Animals
MH  - Arthritis/immunology
MH  - Autoimmunity/*immunology
MH  - Basement Membrane/immunology
MH  - Cecal Diseases/immunology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Immunologic
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Mercuric Chloride/immunology
MH  - Rats
MH  - Rats, Inbred BN
MH  - Th2 Cells
MH  - Vasculitis/*immunology
PMC - PMC1782572
EDAT- 2004/09/24 05:00
MHDA- 2004/11/13 09:00
PMCR- 2005/10/01
CRDT- 2004/09/24 05:00
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
PHST- 2005/10/01 00:00 [pmc-release]
AID - IMM1947 [pii]
AID - 10.1111/j.1365-2567.2004.01947.x [doi]
PST - ppublish
SO  - Immunology. 2004 Oct;113(2):269-76. doi: 10.1111/j.1365-2567.2004.01947.x.