PMID- 15380008
OWN - NLM
STAT- MEDLINE
DCOM- 20041222
LR  - 20040921
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 20
IP  - 7
DP  - 2004 Oct
TI  - Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density 
      in CA1 pyramidal cells and selectively alters acquisition of spatial memory.
PG  - 1865-72
AB  - The hippocampus is highly sensitive to ischemia and is one of the most 
      extensively damaged regions of brain during cardiac arrest. Damage to hippocampus 
      can subsequently lead to learning and memory deficits. The current study used the 
      Morris water maze to characterize spatial learning and memory deficits elicited 
      by 8 min of cardiac arrest with cardiopulmonary resuscitation (CA/CPR) in mice, 
      which is associated with a 25-50% decrease in CA1 neurons. Mice were trained to 
      navigate the water maze prior to CA/CPR or sham surgery (SHAM). They were 
      retested in the water maze on days 7 and 8 postsurgery; both CA/CPR and SHAM 
      groups were able to perform the task at presurgical levels. However, when the 
      hidden platform was moved to a new location, the SHAM mice were able to adapt 
      more quickly to the change and swam a shorter distance in search of the platform 
      than did CA/CPR mice. Thus, CA/CPR did not affect the ability of mice to retain a 
      previously learned platform location, but it did affect their ability to learn a 
      new platform location. This behavioural impairment was correlated with dendritic 
      spine density in the CA1 region of the hippocampus. Data presented here suggest 
      that morphological changes, such as spine density, that occur in neurons that 
      survive CA/CPR may be associated with cognitive impairments.
FAU - Neigh, Gretchen N
AU  - Neigh GN
AD  - Department of Psychology, Townshend Hall, 1885 Neil Avenue Mall, The Ohio State 
      University, Columbus, OH 43210, USA.
FAU - Glasper, Erica R
AU  - Glasper ER
FAU - Kofler, Julia
AU  - Kofler J
FAU - Traystman, Richard J
AU  - Traystman RJ
FAU - Mervis, Ronald F
AU  - Mervis RF
FAU - Bachstetter, Adam
AU  - Bachstetter A
FAU - DeVries, A Courtney
AU  - DeVries AC
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Brain/pathology/physiopathology
MH  - *Cardiopulmonary Resuscitation
MH  - Disease Models, Animal
MH  - Heart Arrest, Induced/*psychology
MH  - Male
MH  - Maze Learning/*physiology
MH  - Memory/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pyramidal Cells/*physiology
MH  - Space Perception/*physiology
MH  - Spinal Cord/cytology/pathology/*physiology
EDAT- 2004/09/24 05:00
MHDA- 2004/12/23 09:00
CRDT- 2004/09/24 05:00
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2004/12/23 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - EJN3649 [pii]
AID - 10.1111/j.1460-9568.2004.03649.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2004 Oct;20(7):1865-72. doi: 10.1111/j.1460-9568.2004.03649.x.