PMID- 15380444
OWN - NLM
STAT- MEDLINE
DCOM- 20050124
LR  - 20061115
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 176
IP  - 2
DP  - 2004 Oct
TI  - Lesion progression and plaque composition are not altered in older apoE-/- mice 
      lacking tumor necrosis factor-alpha receptor p55.
PG  - 227-32
AB  - BACKGROUND: Inflammatory processes are an integral component of the initiation, 
      progression, and destabilization of atherosclerotic lesions. Tumor necrosis 
      factor-alpha (TNF-alpha) is considered a primary mediator of inflammatory 
      processes. METHODS AND RESULTS: The role of TNF-alpha in plaque progression and 
      plaque destabilization was investigated in the innominate arteries of older 
      TNF-alpha receptor p55 deficient mice that were generated on a hyperlipidemic 
      apolipoprotein E deficient background (p55-/- apoE-/-). There were no significant 
      differences in levels of circulating cytokines, plaque progression, plaque 
      composition or features of plaque destabilization in p55-/- apoE-/- compared to 
      wild type (p55+/+ apoE-/-) mice. CONCLUSIONS: Progression and destabilization of 
      advanced atherosclerotic lesions does not seem to be mediated via the TNF-alpha 
      receptor p55.
FAU - Blessing, Erwin
AU  - Blessing E
AD  - Department of Pathobiology, University of Washington, P.O. Box 353410, Seattle, 
      WA 98195, USA.
FAU - Bea, Florian
AU  - Bea F
FAU - Kuo, Cho-chou
AU  - Kuo CC
FAU - Campbell, Lee Ann
AU  - Campbell LA
FAU - Chesebro, Brian
AU  - Chesebro B
FAU - Rosenfeld, Michael E
AU  - Rosenfeld ME
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Apolipoproteins E)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Apolipoproteins E/*genetics/pharmacology
MH  - Arteriosclerosis/genetics/*physiopathology
MH  - Disease Progression
MH  - Hyperlipidemias/genetics/physiopathology
MH  - Mice
MH  - Receptors, Tumor Necrosis Factor/*genetics/physiology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 2004/09/24 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/09/24 05:00
PHST- 2003/12/30 00:00 [received]
PHST- 2004/05/19 00:00 [revised]
PHST- 2004/05/25 00:00 [accepted]
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - S0021-9150(04)00288-6 [pii]
AID - 10.1016/j.atherosclerosis.2004.05.033 [doi]
PST - ppublish
SO  - Atherosclerosis. 2004 Oct;176(2):227-32. doi: 
      10.1016/j.atherosclerosis.2004.05.033.