PMID- 15380825 OWN - NLM STAT- MEDLINE DCOM- 20041202 LR - 20220310 IS - 0736-5748 (Print) IS - 0736-5748 (Linking) VI - 22 IP - 5-6 DP - 2004 Aug-Oct TI - Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning. PG - 247-59 AB - 3,4-methylenedioxymethamphetamine (MDMA) in previous experiments has been shown to induce long-term spatial and sequential learning and memory deficits in adult offspring after exposure to the drug on postnatal (P) days 11-20, but not after exposure on P1-10. Herein we further tested for the effects of MDMA (0, 5, 10 or 20 mg/kg x 2/day) after exposure on P11-20 on reference and working memory in the Morris water maze (MWM), on reference memory in the Barnes maze, and on cued learning in the visible platform version of the MWM. The MWM and Barnes mazes were counterbalanced such that half the litters received the MWM-first and the other half received the Barnes maze first. Effects on MWM performance as a function of test order were observed. For animals that received the Barnes maze first, spatial MWM learning and memory trends were seen but they were not significantly different between MDMA groups and saline controls. For those receiving the MWM-first, there are consistent impairments on all measures in the MDMA groups compared to controls on MWM performance (latency, path length, and cumulative distance from the goal). On probe trials, MDMA animals receiving the MWM-first showed increased distance from the target site compared to controls. There were no MDMA effects seen on cued trials in the MWM or on straight channel swimming trials regardless of test order, indicating that MDMA had no effects on swimming ability or on the skills needed to learn the MWM. Similarly, there were no effects of MDMA on MWM working memory regardless of test order. No MDMA effects on the Barnes maze were found regardless of test order, however, the interpretation of this finding was compromised by the poor performance of the animals on this task. FAU - Vorhees, Charles V AU - Vorhees CV AD - Division of Developmental Biology (MLC 7007), Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. charles.vorhees@cchmc.org FAU - Reed, Tracy M AU - Reed TM FAU - Skelton, Matthew R AU - Skelton MR FAU - Williams, Michael T AU - Williams MT LA - eng GR - DA11902/DA/NIDA NIH HHS/United States GR - DA14269/DA/NIDA NIH HHS/United States PT - Comparative Study PT - Evaluation Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Int J Dev Neurosci JT - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience JID - 8401784 RN - 0 (Hallucinogens) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - Age Factors MH - Aging/drug effects/physiology MH - Animals MH - Animals, Newborn MH - Dose-Response Relationship, Drug MH - Female MH - Hallucinogens/administration & dosage MH - Male MH - Maze Learning/*drug effects/*physiology MH - Memory/*drug effects/*physiology MH - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage MH - Psychomotor Performance/*drug effects/*physiology MH - Rats MH - Rats, Sprague-Dawley EDAT- 2004/09/24 05:00 MHDA- 2004/12/16 09:00 CRDT- 2004/09/24 05:00 PHST- 2004/02/25 00:00 [received] PHST- 2004/06/08 00:00 [revised] PHST- 2004/06/15 00:00 [accepted] PHST- 2004/09/24 05:00 [pubmed] PHST- 2004/12/16 09:00 [medline] PHST- 2004/09/24 05:00 [entrez] AID - S0736-5748(04)00079-6 [pii] AID - 10.1016/j.ijdevneu.2004.06.003 [doi] PST - ppublish SO - Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):247-59. doi: 10.1016/j.ijdevneu.2004.06.003.