PMID- 15381345
OWN - NLM
STAT- MEDLINE
DCOM- 20050616
LR  - 20151119
IS  - 0167-4943 (Print)
IS  - 0167-4943 (Linking)
VI  - 39
IP  - 3
DP  - 2004 Nov-Dec
TI  - Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose 
      intolerance patients.
PG  - 269-75
AB  - Increased oxidative stress and impaired anti-oxidant defense have been suggested 
      as contributory factors for initiation and progression of complications in 
      diabetes mellitus. Aging itself has been shown to be along with increased 
      oxidative stress and lower anti-oxidant defense. We aimed at investigating 
      oxidative stress and anti-oxidant enzymes in 61 elderly subjects. Fifteen healthy 
      individuals (group 1, mean age 72.2 +/- 5.13), 13 glucose intolerant patients 
      (group 2, mean age 71.7 +/- 4.9), 19 patients with type 2 diabetes mellitus 
      (T2DM) without any complication (group 3, mean age 70.0 +/- 6.0), and 14 patients 
      with T2DM with at least one complication (group 4, mean age 69.8 +/- 4.7) were 
      included in the study. Whilst plasma levels for malondialdehyde (MDAP) and 
      erythrocyte malondialdehyde (MDAE) were measured as markers of oxidative stress, 
      activity of erythrocyte superoxide dismutase (SOD), glutathion peroxidase 
      (GSH-Px), and catalase (CAT) were taken as markers of oxidative defense system. 
      MDAP level was significantly elevated in group 4 (P = 0.001). MDAE was elevated 
      in patients with T2DM, particularly in group 4, however, the difference between 
      the groups was of borderline significance (P = 0.07). Whilst CAT was elevated in 
      groups 3 and 4 compared to control subjects (P = 0.025 and 0.002, respectively), 
      no difference was found for SOD between the groups. GSH-Px activity was found to 
      be increased in groups 2, 3 and 4, it did not reach statistical significance (P = 
      0.106). There were significant correlations between CAT and MDAE (P < 0.0001, r = 
      0.056) and MDAP (P = 0.016, r = 0.306). These results suggest that there was an 
      increased oxidative stress in elderly diabetics, however, this is not due to 
      reduced erythrocyte antioxidant defense potential but, rather, increased free 
      radical production possibly due to hyperglycemia.
FAU - Atli, Teslime
AU  - Atli T
AD  - Department of Geriatric Medicine, Ankara University School of Medicine, Cebeci, 
      06110, Turkey. teslimeatli@yahoo.com
FAU - Keven, Kenan
AU  - Keven K
FAU - Avci, Aslihan
AU  - Avci A
FAU - Kutlay, Sim
AU  - Kutlay S
FAU - Turkcapar, Nuran
AU  - Turkcapar N
FAU - Varli, Murat
AU  - Varli M
FAU - Aras, Sevgi
AU  - Aras S
FAU - Ertug, Ergun
AU  - Ertug E
FAU - Canbolat, Orhan
AU  - Canbolat O
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Biomarkers)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Aged
MH  - Aging/*blood
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Catalase/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Male
MH  - Malondialdehyde/blood
MH  - *Oxidative Stress
MH  - Superoxide Dismutase/blood
EDAT- 2004/09/24 05:00
MHDA- 2005/06/17 09:00
CRDT- 2004/09/24 05:00
PHST- 2003/12/17 00:00 [received]
PHST- 2004/04/26 00:00 [revised]
PHST- 2004/04/27 00:00 [accepted]
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2005/06/17 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - S0167494304001219 [pii]
AID - 10.1016/j.archger.2004.04.065 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2004 Nov-Dec;39(3):269-75. doi: 
      10.1016/j.archger.2004.04.065.