PMID- 15381367
OWN - NLM
STAT- MEDLINE
DCOM- 20041026
LR  - 20111107
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 154
IP  - 1
DP  - 2004 Oct 1
TI  - Genomic analyses of primary and metastatic serous epithelial ovarian cancer.
PG  - 16-21
AB  - Epithelial ovarian cancer is the most lethal gynecologic malignancy in the 
      western world. In 75% of patients, peritoneal metastases are found at the time of 
      primary surgery. However, the genetic events leading to the development of 
      ovarian tumors and to the genetic progression toward metastasis remain unclear. 
      To gain insight into this issue, the types and patterns of DNA copy number 
      changes were compared between primary ovarian tumors and their respective 
      metastases by using comparative genomic hybridization (CGH) and fluorescence in 
      situ hybridization (FISH). The genetic alterations (deletions and amplifications) 
      detected by CGH were similar in the primary tumors and in their respective 
      metastases. Moreover, the FISH results show a similar pattern of chromosomal 
      abnormalities. Our results imply that the major gross genetic changes in ovarian 
      cancer take place in the primary tumor, and the additional genetic changes that 
      may occur in the metastases are not detectable by CGH.
FAU - Israeli, Ofir
AU  - Israeli O
AD  - Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, Tel 
      Hashomer 52621, Ramat-Gan, Israel.
FAU - Gotlieb, Walter H
AU  - Gotlieb WH
FAU - Friedman, Eitan
AU  - Friedman E
FAU - Korach, Jacob
AU  - Korach J
FAU - Friedman, Eddy
AU  - Friedman E
FAU - Goldman, Boleslaw
AU  - Goldman B
FAU - Zeltzer, Assaf
AU  - Zeltzer A
FAU - Ben-Baruch, Gilad
AU  - Ben-Baruch G
FAU - Rienstein, Shlomit
AU  - Rienstein S
FAU - Aviram-Goldring, Ayala
AU  - Aviram-Goldring A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
EIN - Cancer Genet Cytogenet. 2011 Aug;204(8):476. Zeltser, Assaf [corrected to 
      Zeltzer, Assaf]
MH  - Chromosome Deletion
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Nucleic Acid Hybridization/methods
MH  - Ovarian Neoplasms/*genetics
MH  - Peritoneal Neoplasms/genetics/secondary
EDAT- 2004/09/24 05:00
MHDA- 2004/10/27 09:00
CRDT- 2004/09/24 05:00
PHST- 2003/12/05 00:00 [received]
PHST- 2004/01/27 00:00 [revised]
PHST- 2004/02/06 00:00 [accepted]
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - S0165-4608(04)00074-3 [pii]
AID - 10.1016/j.cancergencyto.2004.02.006 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Oct 1;154(1):16-21. doi: 
      10.1016/j.cancergencyto.2004.02.006.