PMID- 15381373
OWN - NLM
STAT- MEDLINE
DCOM- 20041026
LR  - 20071115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 154
IP  - 1
DP  - 2004 Oct 1
TI  - A case of infantile acute lymphoblastic leukemia presenting with rearrangement of 
      MLL at 11q23 and apparent insertion or translocation at 10p12.
PG  - 57-9
AB  - We report the case of an 11-month-old patient with a clinical diagnosis of 
      infantile acute lymphoblastic leukemia and an MLL (11q23) rearrangement in 69% of 
      nuclei, revealed with interphase fluorescence in situ hybridization (FISH). 
      Routine chromosome analysis of the bone marrow showed a very subtle rearrangement 
      involving the short arm of chromosome 10 and the long arm of chromosome 11 in the 
      abnormal cells. To clarify the nature of this rearrangement, we hybridized the 
      MLL break-apart probe to previously G-banded slides. The rearrangement was 
      interpreted as a small inversion within the band 11q23, separating the 5' MLL 
      from the 3' MLL region. This segment on the long arm of chromosome 11 containing 
      the rearranged MLL locus was either inserted in or translocated to the short arm 
      of chromosome 10 at approximately band 10p12. The inversion affecting MLL may 
      have followed insertion or preceded it. Molecular characterization of this 
      rearrangement was not possible, due to limited sample material. There have been 
      previous reports of rearrangements of MLL with the MLLT10 (alias AF10) gene locus 
      at 10p12, including an interstitial inverted insertion of 11q13q23 in one case 
      and insertion of 11q14q23 at 10p12 in another. These both resulted in a large 
      derivative chromosome 10 and transcription of an MLL/MLLT10 fusion product. To 
      our knowledge, the novel and cryptic rearrangement detected in our patient has 
      not been described previously. A follow-up study of the patient's bone marrow at 
      the end of induction therapy showed no morphologic evidence of residual leukemia 
      and both FISH and chromosome analyses were normal.
FAU - Tirado, C A
AU  - Tirado CA
AD  - Cytogenetics Laboratory, Department of Pathology, Duke University Medical Center, 
      Box 3631, Durham, NC 27710, USA. carlostirado@hotmail.com
FAU - Lager, J
AU  - Lager J
FAU - Rosoff, P M
AU  - Rosoff PM
FAU - Golembiski-Ruiz, V
AU  - Golembiski-Ruiz V
FAU - Gong, J Z
AU  - Gong JZ
FAU - Goodman, B K
AU  - Goodman BK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - *Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Mutation
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 2004/09/24 05:00
MHDA- 2004/10/27 09:00
CRDT- 2004/09/24 05:00
PHST- 2003/10/29 00:00 [received]
PHST- 2004/01/14 00:00 [revised]
PHST- 2004/01/22 00:00 [accepted]
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - S0165-4608(04)00037-8 [pii]
AID - 10.1016/j.cancergencyto.2004.01.018 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Oct 1;154(1):57-9. doi: 
      10.1016/j.cancergencyto.2004.01.018.