PMID- 15383137
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20181130
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 6
IP  - 5
DP  - 2004 Oct
TI  - Acute treatment of bipolar depression with adjunctive zonisamide: a retrospective 
      chart review.
PG  - 432-4
AB  - BACKGROUND: This retrospective chart review evaluated the use of zonisamide as 
      adjunctive treatment in patients with bipolar depression. METHOD: The charts of 
      outpatients with bipolar I or II disorder treated with adjunctive zonisamide were 
      reviewed. The efficacy of zonisamide was assessed via comparison of 
      physician-rated Global Assessment of Functioning (GAF) and Clinical Global 
      Impression of Severity (CGI-S) Scale scores at baseline and after 6 weeks of 
      therapy using paired t-tests. Patients who scored < or = 2 on the CGI-S after 6 
      weeks of zonisamide therapy were considered good responders to zonisamide. 
      RESULTS: Charts for 12 patients (four men and eight women) with a mean (+/- SD) 
      age of 39.6 (+/- 7.6) years were evaluated. Patients received a mean (+/- SD) 
      zonisamide dosage of 236 (+/- 68) mg/day. Mean GAF scores significantly improved 
      from 44.0 at baseline to 59.3 at week 6 (P = 0.05). Mean CGI-S scores improved 
      from 4.54 at baseline to 3.42 at week 6, but the change was not statistically 
      significant. Six patients (50.0%) were considered responders to zonisamide. Four 
      patients discontinued zonisamide therapy, two for an adverse event (sedation) and 
      two for lack of efficacy. CONCLUSIONS: Zonisamide may be a useful adjunctive 
      treatment for some patients with bipolar depression. Conclusions from this study 
      are limited due to its retrospective design. Further investigation of zonisamide 
      in the treatment of bipolar depression is warranted.
FAU - Baldassano, Claudia F
AU  - Baldassano CF
AD  - Bipolar Outpatient Program, University of Pennsylvania School of Medicine, 
      Philadelphia, PA 19104-3309, USA. cfb@mail.med.upenn.edu
FAU - Ghaemi, S Nassir
AU  - Ghaemi SN
FAU - Chang, Alice
AU  - Chang A
FAU - Lyman, Alan
AU  - Lyman A
FAU - Lipari, Melissa
AU  - Lipari M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Anticonvulsants)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Isoxazoles)
RN  - 459384H98V (Zonisamide)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Anticonvulsants/*therapeutic use
MH  - Antipsychotic Agents/*therapeutic use
MH  - Bipolar Disorder/diagnosis/*therapy
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Isoxazoles/*therapeutic use
MH  - Male
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Zonisamide
EDAT- 2004/09/24 05:00
MHDA- 2005/02/03 09:00
CRDT- 2004/09/24 05:00
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - BDI143 [pii]
AID - 10.1111/j.1399-5618.2004.00143.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2004 Oct;6(5):432-4. doi: 10.1111/j.1399-5618.2004.00143.x.