PMID- 15385741
OWN - NLM
STAT- MEDLINE
DCOM- 20051114
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 37
IP  - 2
DP  - 2004 Oct 1
TI  - Frequent human leukocyte antigen class I alleles are associated with higher viral 
      load among HIV type 1 seroconverters in Thailand.
PG  - 1318-23
AB  - The loss of viral control by the host may be due to the evolution of viruses with 
      mutations that limit presentation by human leukocyte antigen (HLA) to cytotoxic T 
      cells. The authors hypothesized that the consequence of such evolution might be 
      that persons with common HLA class I alleles would be less able to control 
      viremia, on average, than would those with rare alleles. HLA class I typing was 
      completed for 128 injection drug users who seroconverted in a prospective cohort 
      study in Bangkok, Thailand. Logistic regression was used to model viral load 
      (greater than or equal to the median) at 9 and 12 months after seroconversion 
      with an HLA score that profiled the relative prevalence of each individual's 
      alleles. At 12 months after seroconversion, injection drug users with the most 
      common HLA alleles (highest quartile HLA score) had an almost 4-fold increased 
      risk for higher viral load (> or = 32,055 copies/mL) than injection drug users 
      with less common HLA alleles (adjusted odds ratio, 3.92; 95% confidence interval, 
      1.3-11.8). These findings support the importance of frequency-dependent effects 
      of host genes on HIV type 1 evolution in different populations and suggest that 
      HLA-driven viral evolution critically influences control of viremia in early HIV 
      type 1 infection.
FAU - Nguyen, Lily
AU  - Nguyen L
AD  - Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
FAU - Chaowanachan, Thanyanan
AU  - Chaowanachan T
FAU - Vanichseni, Suphak
AU  - Vanichseni S
FAU - McNicholl, Janet M
AU  - McNicholl JM
FAU - Mock, Philip A
AU  - Mock PA
FAU - Nelson, Robert
AU  - Nelson R
FAU - Hodge, Thomas W
AU  - Hodge TW
FAU - van Griensven, Frits
AU  - van Griensven F
FAU - Choopanya, Kachit
AU  - Choopanya K
FAU - Mastro, Timothy D
AU  - Mastro TD
FAU - Tappero, Jordan W
AU  - Tappero JW
FAU - Hu, Dale J
AU  - Hu DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (HIV Antibodies)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Genes, MHC Class I/*genetics
MH  - HIV Antibodies/*blood
MH  - HIV Infections/*genetics/virology
MH  - HIV Seropositivity
MH  - HIV-1/genetics/immunology/*physiology
MH  - HLA-B Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Substance Abuse, Intravenous/*complications
MH  - Thailand
MH  - Viral Load
EDAT- 2004/09/24 05:00
MHDA- 2005/11/15 09:00
CRDT- 2004/09/24 05:00
PHST- 2004/09/24 05:00 [pubmed]
PHST- 2005/11/15 09:00 [medline]
PHST- 2004/09/24 05:00 [entrez]
AID - 00126334-200410010-00014 [pii]
AID - 10.1097/01.qai.0000127059.98621.55 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2004 Oct 1;37(2):1318-23. doi: 
      10.1097/01.qai.0000127059.98621.55.